{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:48:01Z","timestamp":1782452881569,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the relationship between prostate\u2010specific antigen (PSA) kinetics and prognosis in metastatic castration\u2010sensitive prostate cancer (mCSPC) cases has been examined in a pivotal randomized control trial and real\u2010world studies, there are no known reports regarding which PSA kinetic parameter is the most valuable surrogate marker for indicating survival outcome. The present retrospective multicenter study investigated the relationship of absolute PSA value and relative PSA response rate with the prognosis of mCSPC patients in real\u2010world clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among patients diagnosed with mCSPC, 114 who received androgen receptor signaling inhibitors (ARSI) between June 2019 and September 2024 were included. Outcome measures included achievement of absolute PSA value and relative PSA response at 3\u2009months following initiation of first\u2010line ARSI treatment, survival outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up period was 20\u2009months. The results were insufficient to demonstrate a difference in terms of Overall survival (OS) stratified by achievement of PSA \u2264\u20090.2\u2009ng\/mL (hazard ratio [HR] 0.44, 95% confidence interval [CI] 0.16\u20131.23;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.119). Nevertheless, patients who achieved a \u2265\u200999% decline in PSA showed significantly better OS as compared with those who did not (HR 0.27, 95% CI 0.10\u20130.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). After adjustment for liver metastasis and EOD \u2265\u20093, achievement of PSA decline \u2265\u200999% was associated with better OS (HR\u2009=\u20090.17, 95% CI 0.05\u20130.62;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results show the usefulness of PSA decline \u2265\u200999% as a prognostic marker for mCSPC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70533","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:51:58Z","timestamp":1780379518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Absolute\n                    <scp>PSA<\/scp>\n                    Value and Relative\n                    <scp>PSA<\/scp>\n                    Response Rate on Overall Survival in Patients With Metastatic Castration\u2010Sensitive Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-359X","authenticated-orcid":false,"given":"Toru","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Urology Takarazuka City Hospital  Takarazuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Urology Takarazuka City Hospital  Takarazuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Nishizaki","sequence":"additional","affiliation":[{"name":"Department of Urology Takarazuka City Hospital  Takarazuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Urology Takarazuka City Hospital  Takarazuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Urology Kawanishi City Medical Center  Kawanishi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kaizuka","sequence":"additional","affiliation":[{"name":"Department of Urology Kawanishi City Medical Center  Kawanishi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kawanishi City Medical Center  Kawanishi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-7198","authenticated-orcid":false,"given":"Yoshikazu","family":"Togo","sequence":"additional","affiliation":[{"name":"Department of Urology Kawanishi City Medical Center  Kawanishi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Motoki","sequence":"additional","affiliation":[{"name":"Department of Urology Nishinomiya Municipal Central Hospital  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Nishinomiya Municipal Central Hospital  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Urology Nishinomiya Municipal Central Hospital  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903307"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00799"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903835"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30082-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119115"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00367-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16449"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.8751"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.036"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.11.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24847"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24754"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2024.102140"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24885"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2024.09.028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14294-7"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.70533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:18:36Z","timestamp":1782451116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/iju.70533"],"URL":"https:\/\/doi.org\/10.1111\/iju.70533","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70533"}}