{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:06:24Z","timestamp":1785330384364,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the incidence, timing, and clinical predictors of radiation\u2010induced hematuria following robotic stereotactic body radiation therapy (SBRT) for localized prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center cohort study included 397 patients treated with robotic SBRT between 2013 and 2019 for localized prostate cancer. All patients received 36.25\u2009Gy in 5 fractions with the urethral sparing technique. Radiation\u2010induced hematuria was defined as gross hematuria or clinically significant microscopic hematuria without alternative etiology. Incidence, time to first event, and related interventions were assessed. Severity was graded using CTCAE version 5.0. Candidate predictors were selected based on the literature. Cox proportional hazards modeling identified clinical predictors of radiation\u2010induced hematuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At a median follow\u2010up of 56\u2009months (IQR 29\u201379), 48 patients (12.1%) developed radiation\u2010induced hematuria, occurring at a median of 30\u2009months (IQR 19\u201349) after radiation treatment. Severe events (grade 3) were rare, affecting only 5 patients (1.3%). Diagnostic cystoscopy was performed in 35 patients (72.9%) and 6 patients (12.5%) required a total of 10 therapeutic interventions. Diabetes was the only independent predictor (HR 2.63, 95% CI 1.37\u20135.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), while age, anticoagulant use, prostate volume, and Charlson Comorbidity Index showed no significant association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radiation\u2010induced hematuria following robotic SBRT is predominantly low\u2010grade and late\u2010occurring, confirming the favorable genitourinary toxicity profile. These findings help clinicians better understand this SBRT\u2010related toxicity and provide more accurate patient counseling regarding timing and severity of potential hematuria. Diabetes was identified as an independent risk factor and may have clinical implications; however, whether optimization of glycemic control reduces hematuria risk remains uncertain and requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70568","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:13:16Z","timestamp":1783581196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diabetes Is an Independent Risk Factor for Radiation\u2010Induced Hematuria After Robotic Stereotactic Body Radiotherapy for Prostate Cancer"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4140-186X","authenticated-orcid":false,"given":"Lucia","family":"Elting","sequence":"first","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-674X","authenticated-orcid":false,"given":"Jamil","family":"Almohtasib","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio F. San","family":"Francisco","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-1679","authenticated-orcid":false,"given":"Agust\u00edn","family":"P\u00e9rez\u2010Londo\u00f1o","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-0557","authenticated-orcid":false,"given":"Ra'ad","family":"Al\u2010Faouri","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Aronovitz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakriti","family":"Mehta","sequence":"additional","affiliation":[{"name":"Rush Medical College  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Gershman","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-2558","authenticated-orcid":false,"given":"Aria F.","family":"Olumi","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Aghdam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology New York University Langone Hospital\u2010Long Island  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2018.08.002"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2403365"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31131\u20106"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(25)00205\u20100"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.12.003"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.23"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010025\u201006040\u20102"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2024.02.011"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2024.04.035"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010015\u20100351\u20106"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197757"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.026"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urpr.2015.01.001"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.05.040"},{"key":"e_1_2_13_16_1","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 [Internet]","author":"National Cancer Institute","year":"2017"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.8006"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(98)00460\u2010x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2506017"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(22)00544\u20107"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357908909039849"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.20.2579"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2025.01.014"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.07.007"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2022.05.021"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.70568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:31:42Z","timestamp":1785328302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/iju.70568"],"URL":"https:\/\/doi.org\/10.1111\/iju.70568","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70568"}}