{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:25:47Z","timestamp":1787664347937,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effect of dutasteride on benign prostate lesions and Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) scores remains uncertain. We evaluated its impact on pathologically benign transition zone (TZ) PI\u2010RADS 3 lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed 3104 multiparametric magnetic resonance imaging (mp\u2010MRI) scans (March 2019\u2013November 2023). Patients undergoing MRI\u2010ultrasound fusion biopsy for PI\u2010RADS 3 lesions with \u2265\u20092 mp\u2010MRI scans were evaluated. After exclusions, dutasteride users formed the study group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) and non\u2010users the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960). Demographics, prostate\u2010specific antigen (PSA), PSA density, prostate volume, pre\u2010biopsy\/control mp\u2010MRI characteristics and PI\u2010RADS scores were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean dutasteride use was 12.1\u2009months. Lesion size decreased in both groups, more so in the study group. Within the study group, mean lesion apparent diffusion coefficient (ADC) increased and the T2\u2010weighted (T2WI) lesion\/transition\u2010zone ROI ratio decreased whereas neither changed in controls; on between\u2010group comparison, the ADC increase was significantly greater but the T2WI ratio change was not. Complete lesion disappearance was significantly more frequent in the study group and remained an independent predictor on multivariable analysis; PI\u2010RADS up\/downgrading and new\u2010lesion rates were similar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In benign TZ PI\u2010RADS 3 lesions, dutasteride did not affect PI\u2010RADS up\u2010\/downgrading of persistent lesions but was independently associated with a higher rate of complete lesion disappearance, a greater reduction in lesion size, and a greater increase in lesion ADC; the T2WI ratio change did not differ between groups. Because these changes can make benign lesions appear less conspicuous, dutasteride use should be conveyed to the radiologist interpreting follow\u2010up mp\u2010MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70585","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:41:52Z","timestamp":1785314512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Dutasteride Treatment on Subsequent Multiparametric Prostate Magnetic Resonance Imaging Sequences and\n                    <scp>PI<\/scp>\n                    \u2010\n                    <scp>RADS<\/scp>\n                    Score in Patients With\n                    <scp>PI<\/scp>\n                    \u2010\n                    <scp>RADS<\/scp>\n                    3 Lesions in the Transitional Zone"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-1163","authenticated-orcid":false,"given":"Sami","family":"Sekkeli","sequence":"first","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7147-8288","authenticated-orcid":false,"given":"Akif","family":"Erbin","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-7664","authenticated-orcid":false,"given":"Feyzi Sinan","family":"Erdal","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8300-2682","authenticated-orcid":false,"given":"Ezgi","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Department of Radiology Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-129X","authenticated-orcid":false,"given":"Caglar","family":"Dizdaroglu","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-9861","authenticated-orcid":false,"given":"Rustu","family":"Turkay","sequence":"additional","affiliation":[{"name":"Department of Radiology Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.09.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12431"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4858-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25891"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210916"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201010859\u20109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54464-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-023-01235-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04634-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14020193"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010014\u20101258\u20109"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.70585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:16:51Z","timestamp":1787663811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/iju.70585"],"URL":"https:\/\/doi.org\/10.1111\/iju.70585","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2025-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70585"}}