{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:25:48Z","timestamp":1787664348857,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Prostate\u2010specific membrane antigen positron emission tomography (PSMA\u2010PET) is a sensitive imaging modality for detecting recurrent prostate cancer following definitive local therapy. However, evidence on\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010labeled PSMA tracers in Japanese patients with biochemical recurrence (BCR) remains limited. The aim of this study was to examine the recurrence site distribution by [\n                      <jats:sup>18<\/jats:sup>\n                      F]PSMA\u20101007 PET in patients with BCR and identify factors associated with metastatic disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 129 patients with prostate cancer who developed BCR after definitive local therapy and underwent [\n                      <jats:sup>18<\/jats:sup>\n                      F]PSMA\u20101007 PET. The primary endpoint was the distribution of recurrence sites detected by PSMA\u2010PET. Secondary endpoints included clinicopathological factors associated with metastatic disease. Exploratory endpoints involved outcomes of lesion\u2010directed therapy following PSMA\u2010PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PSMA\u2010PET identified recurrent lesions in 83% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009107), including local recurrence in 40% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951), lymph node metastasis in 43% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955), and bone metastasis in 26% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933); sites were not mutually exclusive. Metastatic lesions were detectable even at low prostate\u2010specific antigen (PSA) levels (\u2264\u20091.0\u2009ng\/mL). In multivariate analysis, Grade Group \u2265\u20094 was independently associated with metastatic disease (odds ratio [OR], 2.65; 95% confidence interval [CI], 1.06\u20136.77), whereas a PSA doubling time \u2265\u20098.7\u2009months was independently associated with a lower likelihood of metastasis (OR, 0.12; 95% CI, 0.05\u20130.27). Among 55 patients who underwent lesion\u2010directed therapy, PSA declines \u2265\u200990% were observed in 60% of cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this Japanese cohort with BCR, [\n                      <jats:sup>18<\/jats:sup>\n                      F]PSMA\u20101007 PET delineated recurrence patterns and identified clinicopathological factors associated with metastatic disease. PSMA\u2010PET may provide clinically relevant information to support individualized salvage treatment strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70587","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:13:05Z","timestamp":1785485585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    ]\n                    <scp>PSMA<\/scp>\n                    \u20101007\n                    <scp>PET<\/scp>\n                    \u2013Based Recurrence Site Distribution and Predictors of Metastatic Disease in Patients With Biochemical Recurrence of Prostate Cancer"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-5152","authenticated-orcid":false,"given":"Koji","family":"Hatano","sequence":"first","affiliation":[{"name":"Department of Urology The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-2395","authenticated-orcid":false,"given":"Tadashi","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Osaka Graduate School of Medicine  Suita Japan"},{"name":"Institute for Radiation Sciences The University of Osaka  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takero","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Osaka Graduate School of Medicine  Suita 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