{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:25:53Z","timestamp":1787664353961,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Olaparib has demonstrated clinical benefit in patients with metastatic castration\u2010resistant prostate cancer (mCRPC) harboring\n BRCA<\/jats:italic>\n pathogenic or likely pathogenic variants (PVs) in randomized clinical trials; however, multicenter real\u2010world data in Japanese patients remain limited.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This multicenter retrospective study included Japanese patients with mCRPC who received olaparib between 2021 and 2025 at four institutions. Eligible patients had pathogenic or likely pathogenic\n BRCA1\/2<\/jats:italic>\n variants identified by comprehensive genomic profiling or\n BRCA<\/jats:italic>\n \u2010specific testing (BRACAnalysis). Disease progression was defined as prostate\u2010specific antigen (PSA) progression or radiographic progression. Overall survival (OS) and progression\u2010free survival (PFS) were estimated using the Kaplan\u2013Meier method.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 128 patients undergoing comprehensive genomic profiling, 18 (14%) were identified as having\n BRCA<\/jats:italic>\n PVs, of whom 13 received olaparib. Among 239 patients tested by BRACAnalysis, 14 (6%) harbored\n BRCA<\/jats:italic>\n PVs and all received olaparib. Overall, 27 patients with mCRPC harboring\n BRCA<\/jats:italic>\n PVs were analyzed. The median duration of olaparib treatment was 8\u2009months, with three patients treated for more than 30\u2009months. One\u2010year OS rate was 80.6%, with a median OS of 18.4\u2009months, and 1\u2010year PFS rate was 27.2% with a median PFS of 7.6\u2009months. Grade 3 anemia occurred in 33% of patients and was manageable, with no grade 4 or 5 events observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This multicenter retrospective study provides real\u2010world data on olaparib treatment in Japanese patients with mCRPC harboring\n BRCA<\/jats:italic>\n PVs. The observed outcomes and safety profile were generally consistent with previous reports, although interpretation is limited by the small sample size, retrospective design, and heterogeneity of prior treatments.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/iju.70590","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T10:37:37Z","timestamp":1786012657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Outcomes of Olaparib Treatment in Japanese Patients With Metastatic Castration\u2010Resistant Prostate Cancer Harboring\n \n BRCA<\/i>\n <\/scp>\n Pathogenic or Likely Pathogenic Variants"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-1680","authenticated-orcid":false,"given":"Yosuke","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Science Tokyo Tokyo 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