{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:25:48Z","timestamp":1787664348940,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Docetaxel (DTX) is commonly employed in patients with castration\u2010resistant prostate cancer (CRPC) following failure of androgen receptor signaling inhibitors (ARSIs). However, the impact of prior ARSI treatment on the efficacy of subsequent DTX therapy remains unclear. This study aimed to compare oncological outcomes between enzalutamide (ENZ)\u2013DTX and abiraterone acetate plus prednisolone (ABI)\u2013DTX sequential treatment strategies in patients with CRPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ENABLE study for PCa was an investigator\u2010initiated, multicenter, randomized controlled trial conducted in Japan to compare ENZ and ABI. This subanalysis evaluated the efficacy of subsequent DTX therapy in patients who had received either ENZ or ABI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between February 2015 and July 2019, 203 patients were enrolled, of whom 184 were randomized to receive ENZ or ABI (92 per arm). Among them, 20 and 21 patients subsequently initiated DTX therapy following ENZ and ABI, respectively. Median prostate cancer\u2010specific survival (PCSS) in the ENZ\u2013DTX and ABI\u2013DTX groups was 22.7 and 32.1\u2009months, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1724). Median PCSS from the initiation of DTX was 16.1\u2009months in the ENZ\u2013DTX group and 25.3\u2009months in the ABI\u2013DTX group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0966). In the overall cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941), patients who received additional ARSIs after ARSI\u2013DTX therapy had significantly longer PCSS from the initiation of DTX compared with those who did not (median 21.6 vs. 13.8\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0157).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ENZ\u2013DTX and ABI\u2013DTX sequential therapies demonstrated comparable survival outcomes in patients with CRPC. Notably, the administration of additional ARSIs following ARSI\u2013DTX therapy may confer a survival benefit, suggesting a potential role for continued ARSI use in this treatment sequence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The trial was registered with the University Hospital Medical Information Network (UMIN) Center under the identifier UMIN000015529 on November 1, 2014<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70599","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:26:46Z","timestamp":1786703206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Enzalutamide\u2013Docetaxel Versus Abiraterone\u2013Docetaxel Therapy in Castration\u2010Resistant Prostate Cancer: A Subanalysis of the\n                    <scp>ENABLE<\/scp>\n                    Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6268-9266","authenticated-orcid":false,"given":"Manabu","family":"Kamiyama","sequence":"first","affiliation":[{"name":"Department of Urology University of Yamanashi Graduate School of Medical Sciences  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-9100","authenticated-orcid":false,"given":"Kouji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-3678","authenticated-orcid":false,"given":"Takahiko","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Urology University of Yamanashi Graduate School of Medical Sciences  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Urology Toyama Prefectural Central Hospital  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-5381","authenticated-orcid":false,"given":"Yuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Fukui\u2010Ken Saiseikai Hospital  Fukui Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-0995","authenticated-orcid":false,"given":"Koji","family":"Mita","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima City North Medical Center Asa Citizens Hospital  Hiroshima Hiroshima 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