{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:25:47Z","timestamp":1787664347363,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salvage radical prostatectomy (sRP) is a potentially curative treatment for localized recurrence after radiation therapy for prostate cancer; however, nationwide real\u2010world perioperative outcomes remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective descriptive study using the Japanese National Clinical Database (NCD). Patients who underwent sRP after radiation therapy were identified, and perioperative, functional, and pathological outcomes were summarized descriptively according to surgical approach and prior radiation modality without comparative statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 162 patients were included. The median age was 71\u2009years, and high\u2010risk features were common (Gleason score \u2265\u20098, 49.4%; pathological stage \u2265\u2009pT3, 45.7%). Robot\u2010assisted surgery was performed in 88.3% of cases. The median operative time was 254.5\u2009min, and estimated blood loss was 101\u2009mL. Blood transfusion was required in 4.3% of patients. Major complications (Clavien\u2013Dindo grade\u2009\u2265\u2009III) occurred in 4.9%, with one postoperative death (0.6%). Operative time and blood loss tended to be higher in patients with prior BT than EBRT, whereas major complication rates were comparable. Positive surgical margins were observed in 24.1%, and extraprostatic extension in 36.4%. Early continence recovery was limited, with 27.2% of patients using 0\u20131 pad\/day at 1\u2009month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nationwide NCD study provides contemporary real\u2010world data regarding perioperative outcomes after salvage radical prostatectomy in Japan. Although perioperative morbidity appeared acceptable in appropriately selected patients, these findings should be interpreted descriptively because formal comparative analyses were not performed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70602","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T08:34:07Z","timestamp":1786782847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Outcomes of Salvage Radical Prostatectomy After Radiation Therapy: A Nationwide Analysis Using the National Clinical Database of Japan"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-7497","authenticated-orcid":false,"given":"Kazutoshi","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9536-8766","authenticated-orcid":false,"given":"Ami","family":"Makita","sequence":"additional","affiliation":[{"name":"Department of Healthcare Quality Assessment Graduate School of Medicine, The University of Tokyo  Tokyo Japan"},{"name":"Department of Health Data Science Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2966-6476","authenticated-orcid":false,"given":"Daisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Urology Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3337-7595","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Healthcare Quality Assessment Graduate School of Medicine, The University of Tokyo  Tokyo Japan"},{"name":"Department of Health Data Science Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-2477","authenticated-orcid":false,"given":"Takahiro","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-6676","authenticated-orcid":false,"given":"Eiji","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Urology St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15609"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2008.07570.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.01.022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000327"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15561"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010019\u201002683\u20100"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"8271","article-title":"Robotic\u2010Assisted Laparoscopic Versus Open Salvage Radical Prostatectomy Following Radiotherapy","volume":"23","author":"Kenney P. A.","year":"2016","journal-title":"Canadian Journal of Urology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.02.041"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.70602","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:16:46Z","timestamp":1787663806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/iju.70602"],"URL":"https:\/\/doi.org\/10.1111\/iju.70602","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70602"}}