{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:05Z","timestamp":1790582225316,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study aimed to evaluate the impact of grade group (GG) and intraductal carcinoma of the prostate (IDC\u2010P), as established prognostic factors, on clinical endpoints in metastatic hormone\u2010sensitive prostate cancer (mHSPC) patients treated with androgen receptor signaling inhibitors (ARSIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 147 patients with mHSPC treated with androgen deprivation therapy and ARSIs (abiraterone acetate, enzalutamide, or apalutamide). Associations between clinicopathological factors, including GG 5 and IDC\u2010P, and prostate\u2010specific antigen progression\u2010free survival (PSA\u2010PFS), cancer\u2010specific survival (CSS), and overall survival (OS) were evaluated by Kaplan\u2013Meier analysis and Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GG 5 was identified in 66% of patients, and IDC\u2010P was present in 51% of patients. GG 5 was an independent predictor of PSA\u2010PFS, whereas IDC\u2010P was not. In contrast, IDC\u2010P was independently associated with poorer CSS, while GG was not. Neither IDC\u2010P nor GG was significantly associated with OS. The combined evaluation of GG 5 and IDC\u2010P showed the best prognostic predictive ability for PSA\u2010PFS, CSS, and OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with ARSI\u2010treated mHSPC, both GG 5 and IDC\u2010P are important prognostic factors, although they play distinct roles in predicting clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70630","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:44:06Z","timestamp":1788576246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Prognostic Roles of Grade Group and Intraductal Carcinoma of the Prostate in Metastatic Hormone\u2010Sensitive Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-8525","authenticated-orcid":false,"given":"Junichi","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-0369","authenticated-orcid":false,"given":"Hisanori","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monta","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-8839","authenticated-orcid":false,"given":"Yuki","family":"Masuo","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7540-1812","authenticated-orcid":false,"given":"Takahiro","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Yanishi","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9661-5605","authenticated-orcid":false,"given":"Katsunori","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Pathology Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidefumi","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical 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