{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:10Z","timestamp":1790582230379,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate perioperative safety, pathological outcomes, and oncological outcomes of en bloc resection of bladder tumor (ERBT) in a large multicenter real\u2010world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 668 patients who underwent ERBT at five institutions. Perioperative and pathological outcomes were assessed in the overall cohort. Recurrence\u2010free survival (RFS) was evaluated in patients with pathologically confirmed non\u2010muscle\u2010invasive bladder cancer (NMIBC) without a history of upper tract urothelial carcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009551). Clinicopathological prognosticators of recurrence were identified using Cox proportional hazards regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age was 73\u2009years, and the median maximum tumor diameter was 15\u2009mm. The median operative time and postoperative catheterization period were 48\u2009min and 3\u2009days, respectively. Perioperative complications occurred in 60 patients (9.0%), including eight (1.2%) with Clavien\u2013Dindo Grade III or higher complications. Detrusor muscle was identified in 77.2% of evaluable specimens. Final pathology showed pTa, pT1, pTis, and pT2 disease in 377 (56.4%), 239 (35.8%), 16 (2.4%), and 25 patients (3.7%), respectively. With a median follow\u2010up of 42\u2009months, the estimated 1\u2010, 2\u2010, and 5\u2010year RFS rates were 80.9%, 73.2%, and 57.1%, respectively. RFS did not differ significantly between pTa and pT1 disease (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.39). Patients presenting with recurrent tumors had a significantly higher risk of subsequent intravesical recurrence than those with primary tumors (HR 2.06, 95% CI 1.38\u20133.07;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ERBT demonstrated favorable perioperative safety and acceptable oncological outcomes in this large multicenter cohort. Post\u2010ERBT recurrence remained strongly influenced by prior recurrence history, highlighting the importance of risk\u2010adapted postoperative management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70634","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:30:41Z","timestamp":1789011041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Safety and Long\u2010Term Oncological Outcomes of En Bloc Resection of Bladder Tumor: A Multicenter Real\u2010World Study of 668 Patients"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-0712","authenticated-orcid":false,"given":"Takafumi","family":"Yanagisawa","sequence":"first","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine  Tokyo 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Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-8207","authenticated-orcid":false,"given":"Risa","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Urology National Hospital Organization Okayama Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Kamikubo","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Taneda","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Medical Center  Saitama 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