{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:05Z","timestamp":1790582225977,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K02769"],"award-info":[{"award-number":["25K02769"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe post\u2010recurrence treatment patterns and outcomes after adjuvant nivolumab for urothelial carcinoma in real\u2010world practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients with urothelial carcinoma who underwent radical cystectomy or nephroureterectomy followed by adjuvant nivolumab in the multicenter AGEHA database. Among 141 patients, 40 developed recurrence, excluding non\u2010muscle\u2010invasive bladder recurrence. First\u2010line post\u2010recurrence treatment was categorized as enfortumab vedotin plus pembrolizumab (EVP), enfortumab vedotin (EV), non\u2010EV regimens, or no systemic therapy. Overall survival (OS) was measured from recurrence and progression\u2010free survival (PFS) from initiation of first\u2010line post\u2010recurrence therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 141 patients treated with adjuvant nivolumab, 40 (28%) developed recurrence. First\u2010line post\u2010recurrence treatment was EVP in 10 patients, EV in 15, non\u2010EV regimens in 12, and no systemic therapy in 3. Median time from surgery and nivolumab initiation to recurrence was 5.9 and 4.2\u2009months, respectively. Median OS from recurrence was 27.1, 26.0, and 23.4\u2009months in the EVP, EV, and non\u2010EV groups, respectively, while median PFS from initiation of first\u2010line post\u2010recurrence therapy was 12.9, 7.6, and 8.7\u2009months. Baseline characteristics differed across groups, particularly in recurrence timing and metastatic sites, and EV\u2010based therapy was frequently selected after recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recurrence after adjuvant nivolumab occurred in 28% of patients in real\u2010world practice. Post\u2010recurrence management was heterogeneous, and EV\u2010based therapy was frequently used in this setting. These findings provide hypothesis\u2010generating real\u2010world evidence on treatment sequencing after adjuvant nivolumab and require validation in larger cohorts with longer follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70636","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:36:16Z","timestamp":1789410976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Patterns and Outcomes After Recurrence Following Adjuvant Nivolumab for Urothelial Carcinoma: An\n                    <scp>AGEHA<\/scp>\n                    Real\u2010World Study"],"prefix":"10.1111","volume":"33","author":[{"given":"Izuki","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki 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