{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:05Z","timestamp":1790582225289,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To clarify stage\u2010 and age\u2010specific overall survival (OS) according to histological subtype among surgically treated patients with RCC in Japan, we analyzed a nationwide hospital\u2010based cancer registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the Japanese nationwide hospital\u2010based cancer registry and identified patients newly diagnosed with RCC between 2012 and 2014. Eligible patients underwent surgical treatment and had histologically confirmed clear cell, papillary, or chromophobe RCC with pathological stage (pStage) I\u2013IV according to the UICC TNM classification, 7th edition. Patients treated with radiotherapy or local ablative therapies were excluded. OS was estimated using the Kaplan\u2013Meier method and compared using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 17\u2009935 patients met the inclusion criteria, including 15\u2009745 clear cell, 1340 papillary, and 850 chromophobe RCC cases. The 5\u2010year OS rates for clear cell, papillary, and chromophobe RCC were 91.2%, 89.7%, and 93.5% at pStage I, and declined to 37.5%, 21.7%, and 59.3% at pStage IV, respectively. Age\u2010stratified analyses in pStage I disease revealed progressively worse OS with advancing age across all histological subtypes. Among patients aged \u2265\u200985\u2009years, the 5\u2010year OS rates were 68.2% for clear cell, 50.0% for papillary, and 70.0% for chromophobe RCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nationwide registry\u2010based study provides updated real\u2010world evidence on survival patterns in RCC in Japan. Advanced age was associated with reduced OS even in patients with pStage I disease, highlighting the importance of considering age when interpreting overall survival in surgically treated patients with RCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70639","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:25:18Z","timestamp":1789410318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage\u2010 and Age\u2010Specific Survival According to Histological Subtype in Renal Cell Carcinoma: A Nationwide Hospital\u2010Based Cancer Registry Analysis in Japan"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1813-3879","authenticated-orcid":false,"given":"Chihiro","family":"Kamijo","sequence":"first","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-7958","authenticated-orcid":false,"given":"Takahiro","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"},{"name":"Department of Urology and Molecular Oncology, Graduate School of Medicine Dentistry and Health Sciences Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0387-7215","authenticated-orcid":false,"given":"Takuya","family":"Moriguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"},{"name":"Department of Urology National Hospital Organization Hokkaido Cancer Center  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-8994","authenticated-orcid":false,"given":"Hiroshi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-9054","authenticated-orcid":false,"given":"Ryuji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6695-294X","authenticated-orcid":false,"given":"Nobuo","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-7632","authenticated-orcid":false,"given":"Takashige","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.08.036"},{"key":"e_1_2_10_3_1","unstructured":"National Cancer Center Japan \u201cCancer Statistics in Japan 2024 \u201daccessed March 14 2026 https:\/\/ganjoho.jp\/reg_stat\/statistics\/stat\/cancer\/22_renal.html#anchor1."},{"issue":"1","key":"e_1_2_10_4_1","first-page":"9","article-title":"Active Surveillance for Small Renal Masses","volume":"22","author":"Ray S.","year":"2020","journal-title":"Reviews in Urology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26369"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.06.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.70116"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12826"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt013"},{"key":"e_1_2_10_11_1","volume-title":"International Classification of Diseases for Oncology","author":"Fritz A.","year":"2000"},{"key":"e_1_2_10_12_1","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin L. 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