{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:04Z","timestamp":1790582224766,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate early postoperative and long\u2010term changes in renal function following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) and to identify factors associated with each phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 168 patients who underwent RNU for UTUC between 2007 and 2022. Renal function was assessed using estimated glomerular filtration rate (eGFR). Early postoperative renal function decline (RFD) was defined as the percentage decrease in eGFR from preoperative values to 1\u2009month post\u2010surgery. Factors associated with early postoperative RFD were evaluated using multivariable linear regression analyses. Long\u2010term RFD was assessed using serial eGFR measurements obtained from 1\u2009month after surgery onward and was analyzed with multivariable linear mixed\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up period was 74.5\u2009months. The median preoperative eGFR and early postoperative RFD were 53.1\u2009mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      and 30.4%, respectively. Multivariable analysis demonstrated that lower clinical stage, absence of hydronephrosis, absence of neoadjuvant chemotherapy, and a preoperative eGFR \u2265\u200945\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      were independently associated with greater early postoperative RFD. Overall renal function remained relatively stable following the initial postoperative decline. Multivariable analysis identified hypertension and preoperative proteinuria as independent predictors of progressive long\u2010term RFD. Patients with both hypertension and proteinuria experienced greater long\u2010term RFD compared to those with zero or one risk factor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Predictors of early postoperative RFD differed from those of progressive long\u2010term RFD following RNU. These findings suggest that early and long\u2010term postoperative renal functional changes may need to be considered separately in clinical decision\u2010making and patient counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70643","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:33:36Z","timestamp":1789410816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Predictors of Early Postoperative and Long\u2010Term Renal Function Decline Following Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-4384","authenticated-orcid":false,"given":"Shunya","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Urology Saitama Cancer Center  Saitama Japan"},{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-1373","authenticated-orcid":false,"given":"Yuma","family":"Waseda","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-9792","authenticated-orcid":false,"given":"Masaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-5522","authenticated-orcid":false,"given":"Yudai","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-1580","authenticated-orcid":false,"given":"Hiroshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-8338","authenticated-orcid":false,"given":"Shohei","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-2901","authenticated-orcid":false,"given":"Hajime","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8083","authenticated-orcid":false,"given":"Soichiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-3229","authenticated-orcid":false,"given":"Yasuhisa","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70043"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010016\u20101928\u2010x"},{"key":"e_1_2_12_4_1","unstructured":"National Comprehensive Cancer Network (NCCN) \u201cNCCN Clinical Practice Guidelines in Oncology: Bladder Cancer. 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