{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:46:48Z","timestamp":1791877608784,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated whether prior holmium laser enucleation of the prostate (HoLEP) influences perioperative, oncologic, and continence outcomes following robot\u2010assisted radical prostatectomy (RARP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 419 patients who underwent RARP, including 27 with prior HoLEP, were retrospectively analyzed using 1:2 propensity score matching. Urinary continence was assessed longitudinally using pad counts at scheduled intervals, with 12\u2010month continence as the primary endpoint. Secondary endpoints included perioperative outcomes and biochemical recurrence (BCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences were observed in perioperative outcomes, pathological findings, or BCR\u2010free survival between patients with and without prior HoLEP. At 12\u2009months, functional continence (\u2264\u20091 pad\/day) was achieved in 100.0% of patients without prior HoLEP and in 85.2% of those with prior HoLEP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Kaplan\u2013Meier analysis demonstrated no significant difference in time to recovery (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.068); however, a subset of patients with prior HoLEP experienced persistent incontinence beyond 12\u2009months. Exploratory analyses implied an association between longer adjunctive transurethral coagulation time during HoLEP and worse functional continence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perioperative and oncologic outcomes after RARP were generally comparable regardless of prior HoLEP in this cohort. However, persistent incontinence at 12\u2009months may occur in a subset of patients with prior HoLEP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70651","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:01:35Z","timestamp":1791874895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Prior Holmium Laser Enucleation of the Prostate on Outcomes After Robot\u2010Assisted Radical Prostatectomy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6014-5020","authenticated-orcid":false,"given":"Takato","family":"Nishino","sequence":"first","affiliation":[{"name":"Department of Urology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-7123","authenticated-orcid":false,"given":"Masaki","family":"Shimbo","sequence":"additional","affiliation":[{"name":"Department of Urology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Oguchi","sequence":"additional","affiliation":[{"name":"Department of Urology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Urology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Narimoto","sequence":"additional","affiliation":[{"name":"Department of Urology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Urology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-2727","authenticated-orcid":false,"given":"Fumiyasu","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Urology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1177\/15579883221113203","article-title":"The Efficacy and Safety of HoLEP for Benign Prostatic Hyperplasia With Large Volume: A Systematic Review and Meta\u2010Analysis","volume":"16","author":"Sun F.","year":"2022","journal-title":"American Journal of Men's Health"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"6","article-title":"HoLEP: The New Gold Standard for Surgical Treatment of Benign Prostatic Hyperplasia","volume":"28","author":"Shvero A.","year":"2021","journal-title":"Canadian Journal Of Urology"},{"issue":"7","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1089\/end.2014.0767","article-title":"Robot\u2010Assisted Radical Prostatectomy in Patients With a History of Holmium Laser Enucleation of the Prostate: Feasibility and Evaluation of Initial Outcomes","volume":"29","author":"Gellhaus P. T.","year":"2015","journal-title":"Journal of Endourology"},{"issue":"1","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11701-025-02234-3","article-title":"Does Transurethral Resection of the Prostate Before Robot\u2010Assisted Radical Prostatectomy Have Adverse Effects on Patients Diagnosed With Prostate Cancer: A Comparative Evidence\u2010Based Analysis?","volume":"19","author":"Hu A.","year":"2025","journal-title":"Journal of Robotic Surgery"},{"issue":"4","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s11701-023-01555-5","article-title":"Perioperative, Functional, and Oncologic Outcomes in Patients Undergoing Robot\u2010Assisted Radical Prostatectomy Previous Transurethral Resection of Prostate: A Systematic Review and Meta\u2010Analysis of Comparative Trials","volume":"17","author":"Liu Y.","year":"2023","journal-title":"Journal of Robotic Surgery"},{"key":"e_1_2_12_7_1","article-title":"Impact of Prior Holmium Laser Enucleation of the Prostate on Robot\u2010Assisted Radical Prostatectomy Outcomes: A Systematic Review and Meta\u2010Analysis of Comparative Studies","volume":"21","author":"Ditonno F.","year":"2026","journal-title":"Journal of Endourology"},{"issue":"22","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.3390\/cancers17223685","article-title":"Radical Prostatectomy Following Holmium Laser Enucleation of the Prostate (HoLEP): A Systematic Review of Perioperative, Oncological, and Functional Outcomes","volume":"17","author":"Katsimperis S.","year":"2025","journal-title":"Cancers"},{"issue":"3","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ajur.2023.04.005","article-title":"Optimal Interval for Delayed Retrieval Surgery With Reciprocating Morcellators After Enucleation of Giant Prostatic Hyperplasia in Holmium Laser Enucleation of the Prostate","volume":"11","author":"Endo F.","year":"2024","journal-title":"Asian Journal of Urology"},{"issue":"6","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.urology.2010.03.071","article-title":"Anteroposterior Dissection HoLEP: A Modification to Prevent Transient Stress Urinary Incontinence","volume":"76","author":"Endo F.","year":"2010","journal-title":"Urology"},{"issue":"5","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1464-410X.2007.06762.x","article-title":"Robotic Radical Prostatectomy: Outcomes of 500 Cases","volume":"99","author":"Patel V. 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M.","year":"2024","journal-title":"Journal of Urology"},{"issue":"3","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.eururo.2012.05.045","article-title":"Systematic Review and Meta\u2010Analysis of Studies Reporting Urinary Continence Recovery After Robot\u2010Assisted Radical Prostatectomy","volume":"62","author":"Ficarra V.","year":"2012","journal-title":"European Urology"},{"issue":"5","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0022-5347(01)65488-0","article-title":"Risk Factors for Urinary Incontinence After Radical Prostatectomy","volume":"156","author":"Eastham J. 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