{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:55:48Z","timestamp":1790780148541,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the associations of anticholinergic agents and \u03b23\u2010adrenergic receptor agonists (\u03b23\u2010agonists) prescribed for overactive bladder (OAB) with worsening long\u2010term care needs, incident dementia, and frailty among older women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects\/Patients and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used the Shizuoka Kokuho Database, a population\u2010based administrative claims database in Japan. Women aged 65\u201384\u2009years who newly initiated anticholinergic agents or \u03b23\u2010agonists for OAB between 2012 and 2024 and had prescription records consistent with continuous treatment for at least 1 year were included. Follow\u2010up began 12\u2009months after treatment initiation. Stabilized inverse probability of treatment weighting (sIPTW) was used to balance baseline covariates between groups. Primary outcomes were worsening long\u2010term care needs and incident dementia; the secondary outcome was changes in the electronic Frailty Index (eFI). Time\u2010to\u2010event outcomes were analyzed using sIPTW\u2010weighted Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 1 605 anticholinergic and 2 189 \u03b23\u2010agonist users. After sIPTW, baseline covariates were well\u2010balanced. No significant difference was observed in worsening long\u2010term care needs (hazard ratio [HR], 1.03; 95% confidence interval [CI], 0.87\u20131.22). Anticholinergic use was associated with a higher risk of claims\u2010defined incident dementia compared with \u03b23\u2010agonist use (HR, 1.49; 95% CI, 1.04\u20132.13). Median eFI did not differ significantly between the groups during 5\u2009years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among older women with OAB, anticholinergic use was associated with an increased risk of claims\u2010defined incident dementia but not with worsening long\u2010term care needs or frailty compared with \u03b23\u2010agonists. Residual confounding and differential dementia ascertainment cannot be excluded.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70652","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:04:33Z","timestamp":1790777073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Overactive Bladder Pharmacotherapy and Long\u2010Term Care Needs, Dementia, and Frailty in Older Women"],"prefix":"10.1111","volume":"33","author":[{"given":"Kana","family":"Ito","sequence":"first","affiliation":[{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"},{"name":"Division of Urology Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-5191","authenticated-orcid":false,"given":"Yoko","family":"Sato","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6859-535X","authenticated-orcid":false,"given":"Nagato","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-1592","authenticated-orcid":false,"given":"Yoshihiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25532"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-024-06029-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2000.tb04744.x"},{"issue":"2","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0090-4295(98)90009-7","article-title":"Pharmacologic Options for the Overactive Bladder","volume":"51","author":"Wein A. 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