{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:35:52Z","timestamp":1793093752527,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the association of age with PSA kinetics and biochemical control after low\u2010dose\u2010rate brachytherapy (LDR\u2010BT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 347 patients treated with LDR\u2010BT alone without androgen deprivation therapy between 2004 and 2015. Longitudinal PSA changes were evaluated using linear mixed\u2010effects models with natural cubic splines for time. Age was modeled as a continuous fixed effect, including interactions with the spline terms for time. Time to PSA nadir &lt;\u20090.2\u2009ng\/mL was evaluated using Cox proportional hazards models, whereas biochemical recurrence was evaluated using Fine\u2013Gray competing\u2010risk regression with death treated as a competing event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Younger age was significantly associated with slower PSA decline over 5\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Each 1\u2010year increase in age was associated with model\u2010estimated PSA levels relative to baseline that were 4.6%, 6.4%, and 4.3% lower at 1, 3, and 5\u2009years, respectively. This association remained significant after adjustment for Gleason grade group and treatment era and after excluding patients with PSA bounce (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Median time to PSA nadir &lt;\u20090.2\u2009ng\/mL was 54\u2009months in patients aged &lt;\u200965\u2009years and 36\u2009months in those aged \u2265\u200975\u2009years. Increasing age was associated with earlier achievement of PSA nadir &lt;\u20090.2\u2009ng\/mL (HR 1.04 per year, 95% CI 1.02\u20131.06) but was not significantly associated with biochemical recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Age was significantly associated with PSA kinetics following LDR\u2010BT, with younger patients showing slower PSA decline and a delayed achievement of PSA nadir &lt;\u20090.2\u2009ng\/mL. However, these age\u2010related differences were not associated with biochemical recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70653","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:01:07Z","timestamp":1791424867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Younger Age Is Associated With Slower\n                    <scp>PSA<\/scp>\n                    Decline After Low\u2010Dose\u2010Rate Brachytherapy for Localized Prostate Cancer"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7579-0372","authenticated-orcid":false,"given":"Yasushi","family":"Nakai","sequence":"first","affiliation":[{"name":"Department of Urology Nara Medical University  Nara Japan"},{"name":"Department of Prostate Brachytherapy Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-9905","authenticated-orcid":false,"given":"Kenta","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Nara Japan"},{"name":"Department of Prostate Brachytherapy Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-7356","authenticated-orcid":false,"given":"Makito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4494","authenticated-orcid":false,"given":"Kaori","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Department of Prostate Brachytherapy Nara Medical University  Nara Japan"},{"name":"Department of Radiation Oncology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6342-4693","authenticated-orcid":false,"given":"Fumiaki","family":"Isohashi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nara City Hospital  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-7877","authenticated-orcid":false,"given":"Nobumichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Nara Japan"},{"name":"Department of Prostate Brachytherapy Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.04.038"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2021.11.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2024.09.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.02.021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2022.05.003"},{"issue":"22","key":"e_1_2_11_7_1","first-page":"3","article-title":"Biochemical Outcomes and Toxicities in Young Men With Prostate Cancer After Permanent Iodine\u2010125 Seed Implantation: Prospective Cohort Study in 6662 Patients","volume":"1538","author":"Katayama 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