{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:00:17Z","timestamp":1790661617648,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify baseline urodynamic factors associated with persistent detrusor overactivity (DO) after \u03b23\u2010adrenoceptor agonist add\u2010on therapy in men with lower urinary tract symptoms (LUTS)\/overactive bladder (OAB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 270 men with LUTS\/OAB despite \u2265\u20093\u2009months of \u03b11\u2010adrenoceptor antagonist or phosphodiesterase type 5 inhibitor monotherapy. All patients had DO on baseline urodynamics and underwent repeat urodynamic evaluation approximately 3\u2009months after add\u2010on \u03b23\u2010adrenoceptor agonist therapy. Baseline DO was classified as phasic, terminal, or combined. Patients were categorized into the DO disappearance and persistent DO groups. Baseline urodynamic parameters were compared, and logistic regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DO disappeared in 129 patients (47.8%) and persisted in 141 (52.2%). The persistent DO group had significantly lower bladder contractility index (BCI), bladder voiding efficiency (BVE), and bladder outlet obstruction index; the overall DO subtype distribution differed significantly between the groups. In multivariable analysis, with phasic DO as the reference, terminal DO (adjusted odds ratio [OR], 3.08; 95% confidence interval [CI], 1.25\u20137.59), combined DO (adjusted OR, 4.58; 95% CI, 1.86\u201311.28), lower BCI (adjusted OR per 10\u2010unit increase, 0.67; 95% CI, 0.55\u20130.82), and lower BVE (adjusted OR per 10\u2010percentage\u2010point increase, 0.80; 95% CI, 0.66\u20130.97) were independently associated with persistent DO. The adjusted overall subtype effect was significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A baseline terminal DO component and impaired detrusor contractility were independently associated with persistent DO after \u03b23\u2010adrenoceptor agonist add\u2010on therapy. DO subtype and bladder contractility may help identify a potentially treatment\u2010resistant urodynamic phenotype in men with LUTS\/OAB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70654","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:16:16Z","timestamp":1790658976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline Detrusor Overactivity Subtype and Impaired Detrusor Contractility Are Associated With Persistent Detrusor Overactivity After \u03b23\u2010Adrenoceptor Agonist Add\u2010On Therapy in Men With Lower Urinary Tract Symptoms"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7823-2600","authenticated-orcid":false,"given":"Yoshihisa","family":"Matsukawa","sequence":"first","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Urology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-9041","authenticated-orcid":false,"given":"Tsuyoshi","family":"Majima","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Urology Aichi Medical University  Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9942-5847","authenticated-orcid":false,"given":"Shun","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Urology Kasugai City Hospital  Kasugai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-4352","authenticated-orcid":false,"given":"Yushi","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1201-1260","authenticated-orcid":false,"given":"Tomokazu","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-4781","authenticated-orcid":false,"given":"Shohei","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/iju.15454","article-title":"Prevalence and Impact on Daily Life of Lower Urinary Tract Symptoms in Japan: Results of the 2023 Japan Community Health Survey (JaCS 2023)","volume":"31","author":"Mitsui T.","year":"2024","journal-title":"International Journal of Urology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.eururo.2014.01.019","article-title":"What Is the Most Bothersome Lower Urinary Tract Symptom? Individual\u2010 and Population\u2010Level Perspectives for Both Men and Women","volume":"65","author":"Agarwal A.","year":"2014","journal-title":"European Urology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.urology.2012.04.004","article-title":"Effect of Bothersome Overactive Bladder Symptoms on Health\u2010Related Quality of Life, Anxiety, Depression, and Treatment Seeking in the United States: Results From EpiLUTS","volume":"80","author":"Milsom I.","year":"2012","journal-title":"Urology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/JU.0000000000003698","article-title":"Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia (BPH): AUA Guideline Amendment 2023","volume":"211","author":"Sandhu J. S.","year":"2024","journal-title":"Journal of Urology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.eururo.2026.03.020","article-title":"Summary Paper on the 2026 European Association of Urology Guidelines on the Management of Non\u2010Neurogenic Male Lower Urinary Tract Symptoms","volume":"90","author":"Baboudjian M.","year":"2026","journal-title":"European Urology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/iju.13401","article-title":"Clinical Guidelines for Male Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia","volume":"24","author":"Homma Y.","year":"2017","journal-title":"International Journal of Urology"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/JU.0000000000000738","article-title":"Efficacy and Safety of Mirabegron Versus Placebo Add\u2010On Therapy in Men With Overactive Bladder Symptoms Receiving Tamsulosin for Underlying Benign Prostatic Hyperplasia: A Randomized, Phase 4 Study (PLUS)","volume":"203","author":"Kaplan S. A.","year":"2020","journal-title":"Journal of Urology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.euf.2019.10.019","article-title":"Mirabegron Add\u2010On Therapy to Tamsulosin for the Treatment of Overactive Bladder in Men With Lower Urinary Tract Symptoms: A Randomized, Placebo\u2010Controlled Study (MATCH)","volume":"6","author":"Kakizaki H.","year":"2020","journal-title":"European Urology Focus"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","DOI":"10.1111\/luts.70053","article-title":"Efficacy and Safety of Vibegron Add\u2010On Therapy for Persistent Overactive Bladder Symptoms in Benign Prostatic Hyperplasia Patients With Alpha(1)\u2010Blocker Treatment: A Multi\u2010Center Prospective Randomized Controlled Study (VATON Study)","volume":"18","author":"Yoshida M.","year":"2026","journal-title":"Low Urinary Tract Symptoms"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/luts.12091","article-title":"Urodynamic Efficacy and Safety of Mirabegron Add\u2010On Treatment With Tamsulosin for Japanese Male Patients With Overactive Bladder","volume":"8","author":"Wada N.","year":"2016","journal-title":"Low Urinary Tract Symptoms"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4111\/icu.20200471","article-title":"Prevalence and Urodynamic Characteristics of Detrusor Overactivity With Impaired Contractility in the Community\u2010Dwelling Elderly With Non\u2010Neurogenic Lower Urinary Tract Symptoms: Is It From a Single or Two Independent Bladder Dysfunctions?","volume":"62","author":"Jeong S. J.","year":"2021","journal-title":"Investigative and Clinical Urology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00005392-199907000-00035","article-title":"Urodynamic Characterization of Nonobstructive Voiding Dysfunction in Symptomatic Elderly Men","volume":"162","author":"Ameda K.","year":"1999","journal-title":"Journal of Urology"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/nau.25044","article-title":"Two Types of Detrusor Underactivity in Men With Nonneurogenic Lower Urinary Tract Symptoms","volume":"42","author":"Matsukawa Y.","year":"2023","journal-title":"Neurourology and Urodynamics"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.urology.2006.11.019","article-title":"Impaired Detrusor Contractility in Community\u2010Dwelling Elderly Presenting With Lower Urinary Tract Symptoms","volume":"69","author":"Abarbanel J.","year":"2007","journal-title":"Urology"},{"key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.urology.2011.06.020","article-title":"Responsiveness and Minimal Clinically Important Change in Overactive Bladder Symptom Score","volume":"78","author":"Gotoh M.","year":"2011","journal-title":"Urology"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/nau.10066","article-title":"Good Urodynamic Practices: Uroflowmetry, Filling Cystometry, and Pressure\u2010Flow Studies","volume":"21","author":"Sch\u00e4fer W.","year":"2002","journal-title":"Neurourology and Urodynamics"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/nau.70110","article-title":"The Clinical Significance of the Subtypes of Detrusor Overactivity: A Systematic Review","volume":"44","author":"Teji M.","year":"2025","journal-title":"Neurourology and Urodynamics"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.3389\/fruro.2026.1845544","article-title":"Urodynamic Characteristics of Different Types of Detrusor Overactivity in Patients With Benign Prostatic Obstruction","volume":"6","author":"Zeng X.","year":"2026","journal-title":"Frontiers in Urology"},{"key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4103\/tcmj.tcmj_264_20","article-title":"Effects of Different Urodynamic Characteristics on Therapeutic Outcomes of Overactive Bladder Medication in a Real\u2010Life Clinical Practice","volume":"34","author":"Wang H. J.","year":"2022","journal-title":"Tzu Chi Medical Journal"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1001\/jama.1987.03390220074024","article-title":"Detrusor Hyperactivity With Impaired Contractile Function. An Unrecognized but Common Cause of Incontinence in Elderly Patients","volume":"257","author":"Resnick N. M.","year":"1987","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/S0022-5347(05)68995-1","article-title":"Atherosclerosis\u2010Induced Chronic Ischemia Causes Bladder Fibrosis and Non\u2010Compliance in the Rabbit","volume":"161","author":"Azadzoi K. M.","year":"1999","journal-title":"Journal of Urology"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4111\/icu.2016.57.4.249","article-title":"Progressive Changes in Detrusor Function and Micturition Patterns With Chronic Bladder Ischemia","volume":"57","author":"Zhao Z.","year":"2016","journal-title":"Investigative and Clinical Urology"},{"key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/iju.12652","article-title":"Chronic Bladder Ischemia and Oxidative Stress: New Pharmacotherapeutic Targets for Lower Urinary Tract Symptoms","volume":"22","author":"Nomiya M.","year":"2015","journal-title":"International Journal of Urology"},{"key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1464-410X.2006.06735.x","article-title":"Persistent Detrusor Overactivity After Transurethral Resection of the Prostate Is Associated With Reduced Perfusion of the Urinary Bladder","volume":"99","author":"Mitterberger M.","year":"2007","journal-title":"BJU International"},{"key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.juro.2014.12.095","article-title":"Can We Predict Which Patients Will Experience Resolution of Detrusor Overactivity After Transurethral Resection of the Prostate?","volume":"193","author":"Antunes A. A.","year":"2015","journal-title":"Journal of Urology"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.urology.2009.09.065","article-title":"Influence of Detrusor Overactivity on Storage Symptoms Following Potassium\u2010Titanyl\u2010Phosphate Photoselective Vaporization of the Prostate","volume":"75","author":"Cho M. C.","year":"2010","journal-title":"Urology"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.70654","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:16:20Z","timestamp":1790658980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/iju.70654"],"URL":"https:\/\/doi.org\/10.1111\/iju.70654","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70654"}}