{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:08:20Z","timestamp":1792282100037,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072422"],"award-info":[{"award-number":["32072422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102192"],"award-info":[{"award-number":["32102192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Molecular Biology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The oriental fruit fly\n                    <jats:italic>Bactrocera dorsalis<\/jats:italic>\n                    (Hendel) is expanding its distribution to higher latitudes. Our goal in this study was to understand how\n                    <jats:italic>B. dorsalis<\/jats:italic>\n                    adapts to higher latitude environments that are more arid than tropical regions. Cuticular hydrocarbons (CHCs) on the surface of the epicuticle in insects act as a hydrophobic barrier against water loss. The essential decarbonylation reaction in CHC synthesis is catalysed by CYP4G, a cytochrome P450 subfamily protein. Hence, in\n                    <jats:italic>B. dorsalis<\/jats:italic>\n                    it is necessary to clarify the function of the CYP4G gene and its role in desiccation resistance.\n                    <jats:italic>CYP4G100<\/jats:italic>\n                    was identified in the\n                    <jats:italic>B. dorsalis<\/jats:italic>\n                    genome. The complete open reading frame (ORF) encodes a CYP4 family protein (552 amino acid residues) that has the CYP4G\u2010specific insertion. This CYP4G gene was highly expressed in adults, especially in the oenocyte\u2010rich peripheral fat body. The gene can be induced by desiccation treatment, suggesting its role in CHC synthesis and waterproofing. Silencing of\n                    <jats:italic>CYP4G100<\/jats:italic>\n                    resulted in a decrease of CHC levels and the accumulation of triglycerides. It also increased water loss and resulted in higher desiccation susceptibility.\n                    <jats:italic>CYP4G100<\/jats:italic>\n                    is involved in hydrocarbon synthesis and contributes to cuticle waterproofing to help\n                    <jats:italic>B. dorsalis<\/jats:italic>\n                    resist desiccation in arid environments.\n                  <\/jats:p>","DOI":"10.1111\/imb.12803","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T04:08:20Z","timestamp":1658376500000},"page":"772-781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>CYP4G100<\/i>\n                    contributes to desiccation resistance by mediating cuticular hydrocarbon synthesis in\n                    <i>Bactrocera dorsalis<\/i>"],"prefix":"10.1111","volume":"31","author":[{"given":"Tian\u2010Xing","family":"Jing","sequence":"first","affiliation":[{"name":"Key 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