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Long non\u2010coding RNA (lncRNA) influences a wide array of physiological processes, including spermatogenesis. Nevertheless, the precise roles and regulatory mechanisms of lncRNA in testicular aging remain elusive. This investigation delves into the function of\n                    <jats:italic>lncRNA:CR43306<\/jats:italic>\n                    in governing spermatogenesis during testicular aging. Depletion of\n                    <jats:italic>lncRNA:CR43306<\/jats:italic>\n                    in 40\u2010day\u2010old\n                    <jats:italic>Drosophila<\/jats:italic>\n                    testes resulted in the hindrance of spermatogenesis, particularly affecting elongated spermatids, leading to functional senescence. Additionally, differentially expressed gene (DEG) expression analysis through bulk RNA\u2010seq unveiled genes linked to elongated spermatids and cell adhesion. Our findings underscore the pivotal role of\n                    <jats:italic>lncRNA:CR43306<\/jats:italic>\n                    in testicular aging by influencing cell adhesion. These discoveries illuminate the regulatory pathways of lncRNA in testicular aging and offer valuable insights for potential studies and therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1111\/imb.70028","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:31:17Z","timestamp":1769697077000},"page":"284-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>LncRNA<\/scp>\n                    :\n                    <scp>CR43306<\/scp>\n                    modulates testicular aging via cell adhesion in\n                    <scp>\n                      <i>Drosophila<\/i>\n                    <\/scp>"],"prefix":"10.1111","volume":"35","author":[{"given":"Xiaorong","family":"Wang","sequence":"first","affiliation":[{"name":"Clinical Research Center for Reproductive Genetics of Nantong University, Center for Reproductive Medicine Affiliated Maternity and Child 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