{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:56:51Z","timestamp":1790773011254,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Molecular Biology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The recent success of gene drive mosquitoes suppressing malaria signals a new era in vector control. Yet, reliance on secreted, natural peptides poses risks of instability, host toxicity and resistance evolution. We propose synthesizing two transformative technologies to overcome these limits: generative AI for de novo peptide design and precision membrane tethering. Proof\u2010of\u2010concept work shows tethering antimicrobial peptides to the gut epithelium boosts potency 100\u2010fold. Converging these approaches enables engineering of \u2018smart\u2019 immune barriers\u2014AI\u2010designed peptides optimized for stability and specificity, anchored to create impassable surfaces for pathogens. This \u2018t\u2010AMP\u2019 platform potentially offers a durable, fitter and broadly applicable strategy, extending rational vector engineering from mosquitoes to ticks and sandflies, revolutionizing control of multiple neglected diseases.<\/jats:p>","DOI":"10.1111\/imb.70064","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:56:28Z","timestamp":1790769388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The anchor and the architect: Merging gene drive, membrane tethering and generative\n                    <scp>AI<\/scp>\n                    for next\u2010generation vector control"],"prefix":"10.1111","author":[{"given":"Yanan","family":"Wei","sequence":"first","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology Harbin Institute of Technology  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanying","family":"Sun","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology Harbin Institute of Technology  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Kyu","family":"Bang","sequence":"additional","affiliation":[{"name":"Dandicure Inc  Ochang Chung Buk Republic of Korea"},{"name":"Division of Magnetic Resonance Korea Basic Science Institute (KBSI)  Ochang Chung Buk Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-4177","authenticated-orcid":false,"given":"Woo Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology Harbin Institute of Technology  Harbin 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