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In particular, the mechanisms by which cardiac macrophages modulate <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010induced myocardial inflammation remains unclear. In this study, using a mouse <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> model, we showed that \u03b2\u2010catenin\u2010mediated signaling was activated in cardiac macrophages post\u2010<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, especially in Ly\u20106C\u2010positive proinflammatory macrophages. Using a <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7\u2010based \u03b2\u2010catenin reporter cell line, we confirmed the presence of active \u03b2\u2010catenin and its downstream signaling in cardiac macrophages after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>. Moreover, lentivirus\u2010mediated inducible expression of constitutively active \u03b2\u2010catenin revealed that \u03b2\u2010catenin plays a role in promoting the inflammatory response by <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells. Depletion of endogenous macrophages and adoptive transfer of active \u03b2\u2010catenin\u2010expressing <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells resulted in enhancement of acute myocardial inflammation in recipient mice after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, as demonstrated by elevated levels of lymphocyte infiltrates and increased expression of proinflammatory cytokines. However, infarct volume, myocardial tissue repair, and left ventricle function were not influenced by the expression of active \u03b2\u2010catenin in the adoptive transfer assay. Our research has demonstrated that \u03b2\u2010catenin\u2010mediated signaling is important for cardiac macrophages to modulate post\u2010<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> inflammatory responses. These findings may be valuable for developing novel therapeutic strategies for <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/imcb.1019","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T11:20:08Z","timestamp":1515756008000},"page":"100-113","source":"Crossref","is-referenced-by-count":16,"title":["Beta\u2010catenin promotes macrophage\u2010mediated acute inflammatory response after myocardial infarction"],"prefix":"10.1111","volume":"96","author":[{"given":"Ling","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and 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