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Both subsets are selected by double positive thymocytes leading to common features such as\n                    <jats:styled-content style=\"fixed-case\">PLZF<\/jats:styled-content>\n                    expression. Preset T cells correspond to subsets prepositioned in specific tissue locations with preprogrammed versatile effector functions such as antimicrobial functions and possibly also metabolic control and tissue repair activity. Herein, we recall how several groups studying human samples discovered\n                    <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content>\n                    cells as T cells expressing either a restricted T\u2010cell receptors (\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    ) repertoire or homogeneous and singular phenotypic and functional characteristics. We then highlight the main evolutionary features of this subset and its restricting element,\n                    <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                    1 (\n                    <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\n                    \u2010related protein (1) with a striking coevolution of\n                    <jats:styled-content style=\"fixed-case\">TRAV<\/jats:styled-content>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                    1. We introduce another evolutionarily conserved invariant\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    alpha chain coevolving with another\n                    <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\n                    class Ib molecule, called\n                    <jats:styled-content style=\"fixed-case\">MHX<\/jats:styled-content>\n                    , sharing phylogenetic features with\n                    <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                    1. We finally discuss the relationship between\n                    <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content>\n                    cells and other subsets reacting to microbial antigens or to compounds presented by\n                    <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                    1 in light of confounding experimental issues.\n                  <\/jats:p>","DOI":"10.1111\/imcb.1034","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T04:42:57Z","timestamp":1515645777000},"page":"564-572","source":"Crossref","is-referenced-by-count":45,"title":["<scp>MAIT<\/scp>\n                    cells: an historical and evolutionary perspective"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-7719","authenticated-orcid":false,"given":"Olivier","family":"Lantz","sequence":"first","affiliation":[{"name":"Institut Curie PSL Research University Inserm U932 Paris 75005 France"},{"name":"Center of Clinical Investigations CICBT1428 IGR\/Curie Paris 75005 France"},{"name":"Laboratoire d'Immunologie Clinique Institut Curie Paris 75005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Legoux","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University Inserm U932 Paris 75005 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