{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:37:46Z","timestamp":1762252666180,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI080581"],"award-info":[{"award-number":["R01 AI080581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201015 overexpression in eosinophilic gastrointestinal disorders is reported, but <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015\u2032s role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte\u2010overexpressed <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 transgenic mice using Fabpi promoter. The Fabpi\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 (<jats:styled-content style=\"fixed-case\">iIL<\/jats:styled-content>\u201015) transgenic mice showed induced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 levels in the jejunum with a marked increase in jejunum eosinophils. However, no induction of eosinophilia in the blood or any other gastrointestinal segment was observed. Eosinophilia in the jejunum villus was substantially higher in <jats:styled-content style=\"fixed-case\">iIL<\/jats:styled-content>\u201015 mice compared to wild\u2010type mice. In addition, goblet cell hyperplasia was also observed in the jejunum of <jats:styled-content style=\"fixed-case\">iIL<\/jats:styled-content>\u201015 mice. Furthermore, a significant correlation between induced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 transcript and the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 transcripts was observed. Therefore, to further understand the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 mice associated gastrointestinal disorders, we generated <jats:styled-content style=\"fixed-case\">iIL<\/jats:styled-content>\u201015\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018R\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Using these mice, we found that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 has an important role in promoting <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015\u2010induced eosinophilia. As intestinal <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 overexpression is reported in food intolerance, we examined <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content> intolerance in <jats:styled-content style=\"fixed-case\">iIL<\/jats:styled-content>\u201015 mice. The <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010sensitized and challenged <jats:styled-content style=\"fixed-case\">iIL<\/jats:styled-content>\u201015 mice experienced weight loss, diarrhea and eosinophilia in the jejunum. Taken together, our findings demonstrate that intestinal <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 overexpression induces <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018\u2010dependent eosinophilia and immunoglobulins in the intestine that promotes food allergic responses.<\/jats:p>","DOI":"10.1111\/imcb.1036","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T10:35:10Z","timestamp":1515753310000},"page":"273-283","source":"Crossref","is-referenced-by-count":4,"title":["Intestinal overexpression of interleukin (<scp>IL<\/scp>)\u201015 promotes tissue eosinophilia and goblet cell hyperplasia"],"prefix":"10.1111","volume":"96","author":[{"given":"Ahad","family":"Mussarat","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Pulmonary Diseases Tulane Eosinophilic Disorder Center Tulane University School of Medicine New Orleans LA 70112 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