{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:25Z","timestamp":1791895585370,"version":"4.3.4"},"reference-count":69,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IImmunol Cell Biol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dendritic cells (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s) are a diverse family of cells that play a crucial role in linking our innate and adaptive immune system to initiate adequate T\u2010cell responses. They respond to pathogens by triggering the appropriate adaptive immune response that is required to clear invaders while balancing the need to limit tissue damage as a result of inflammation. Perturbation in <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> regulation results in abnormal T\u2010cell homeostasis, leading to development of autoimmune diseases and aberrant responses to pathogens. In recent years, it has become clear that the <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> family is more complex than initially thought in terms of their identification, homeostasis and functions. In this review, we discuss recent findings that improve our understanding of development, and functional specializations of conventional and plasmacytoid <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/imcb.12028","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T07:46:47Z","timestamp":1519372007000},"page":"463-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Homeostatic control of dendritic cell numbers and differentiation"],"prefix":"10.1111","volume":"96","author":[{"given":"Regine J","family":"Dress","sequence":"first","affiliation":[{"name":"Singapore Immunology Network (SIgN) Agency for Science Technology, and Research (A*STAR) Singapore 138648 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia YW","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (SIgN) Agency for Science Technology, and Research (A*STAR) Singapore 138648 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Ginhoux","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (SIgN) Agency for Science Technology, and Research (A*STAR) Singapore 138648 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074950"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2358"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2455"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120340"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1307"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3712"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.03.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai7677"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120204"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091756"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/35004599"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071365"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2768"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.04.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0711384"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.013"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4573"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3865"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1522"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.116"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052003"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610630114"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"p.eaag3009","DOI":"10.1126\/science.aag3009","article-title":"Mapping the human DC lineage through the integration of high\u2010dimensional techniques","volume":"356","author":"See P","year":"2017","journal-title":"Science"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.04.016"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.010"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.79"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.08.030"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.90420"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303138"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.09.002"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.017"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500383"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.01.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110654"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00486"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1518"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1996"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170540"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3200"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12013"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.013"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.020"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.04.006"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6762"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240831"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.005"},{"key":"e_1_2_8_52_1","doi-asserted-by":"crossref","first-page":"e64800","DOI":"10.1371\/journal.pone.0064800","article-title":"Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo","volume":"8","author":"Wu X","year":"2013","journal-title":"PLoS ONE"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132121"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151715"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.04.007"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619863114"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1615"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.011"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091844"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025660"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.027"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25060"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00276-5"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417620112"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.07.024"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.12.037"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.021"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12967"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1462"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3771"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimcb.12028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:04:13Z","timestamp":1695499453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.12028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/imcb.12028"],"URL":"https:\/\/doi.org\/10.1111\/imcb.12028","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"2018-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}