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Evidence from animal and human studies demonstrates a strong link between viral respiratory infections, atopy and the development of asthma. Type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s include <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b1 and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b2, with subtype expression tailored toward the specific viral infection. We hypothesized that exposure to type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s and allergen may interfere with the healthy response to innocuous airway antigen exposure. In this study, we use an ovalbumin (<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>)\u2010induced <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c model of experimental allergic airways disease, where pre\u2010exposure of the airways to <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content> is protective against allergen sensitization, leading to allergen tolerance. We investigated airways pre\u2010exposure with <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content> and type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s on development of allergic airways disease. We demonstrate restoration of allergic airways disease on pre\u2010exposure with allergen and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b2, and not <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b1. Dysfunction in tolerance led to changes in dendritic cell antigen capture\/traffic, T\u2010cell and B\u2010cell responses. Furthermore, exposure to <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b2 with ongoing allergen exposure led to the development of hallmark asthma features, including <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010specific IgE and airways eosinophilia. Data indicate a role for <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b2 in linking viral infection and allergy.<\/jats:p>","DOI":"10.1111\/imcb.12050","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T05:18:43Z","timestamp":1522732723000},"page":"841-851","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IFN\u03b2 inhibits the development of allergen tolerance and is conducive to the development of asthma on subsequent allergen exposure"],"prefix":"10.1111","volume":"96","author":[{"given":"Vanessa S","family":"Fear","sequence":"first","affiliation":[{"name":"Tumour Immunology Group School of Biomedical Sciences University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee Peng","family":"Poh","sequence":"additional","affiliation":[{"name":"Inflammation Group Telethon Kids Institute School of Paediatrics and Child Health Research University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Gorman","sequence":"additional","affiliation":[{"name":"Inflammation Group Telethon Kids Institute School of Paediatrics and Child Health Research University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason C","family":"Waithman","sequence":"additional","affiliation":[{"name":"Inflammation Group Telethon Kids Institute School of Paediatrics and Child Health Research University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W","family":"Fear","sequence":"additional","affiliation":[{"name":"Burn Injury Research Unit School of Surgery University of Western Australia Perth WA 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