{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:06:00Z","timestamp":1791234360391,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the life of a human being, several tons of apoptotic cells and debris are produced. These apoptotic particles should be cleared quickly and accurately from the body, as they may lose their membrane integrity with the probability of leakage of cytotoxic materials and other intracellular antigens into the environment. The action of removing apoptotic particles occurs by a process called efferocytosis. Efferocytosis is a highly regulated balance among a set of <jats:italic>find\u2010me<\/jats:italic>,<jats:italic> eat\u2010me<\/jats:italic> and <jats:italic>don't\u2010eat\u2010me<\/jats:italic> signals. Efferocytosis is accompanied by a suppression of the immune system that can explain its negative role in cancer. Additionally, defects in this process can lead to different diseases. In this review, we aim to describe the mechanism of efferocytosis and evaluate its association with the development of autoimmune diseases, airway inflammation, atherosclerosis and cancer to open a new window for the treatment of these diseases.<\/jats:p>","DOI":"10.1111\/imcb.12206","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T10:43:28Z","timestamp":1537353808000},"page":"124-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Efferocytosis: molecular mechanisms and pathophysiological perspectives"],"prefix":"10.1111","volume":"97","author":[{"given":"Seyed Mohammad","family":"Gheibi Hayat","sequence":"first","affiliation":[{"name":"Department of Genetics School of Medicine Shahid Sadoughi University of Medical Sciences Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bianconi","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases Department of Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pirro","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases Department of Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/461181a"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1244"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3607"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01645"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00474-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00598-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046549"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/37022"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08296"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350284"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706586200"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-107169"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-162404"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.01.025"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22815"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400404"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73527"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2003.09.011"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02160-8"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101157"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00811"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.4161\/23723548.2014.964625"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00141"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01394-13"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910359107"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061781"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10859"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2413"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200907-1061OC"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803503"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.301174"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.02.003"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207781662948"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.167197"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.570838"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.571620"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.108"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009076"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2147"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121623109"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121629109"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-111315-125315"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3566"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2028"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0579-07.2007"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066657"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2730"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03046.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707782793899"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.041"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12614"},{"key":"e_1_2_5_53_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/978-1-4419-9258-1_17","volume-title":"Calreticulin","author":"Sontheimer RD","year":"2003"},{"key":"e_1_2_5_54_1","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.4049\/jimmunol.154.4.1951","article-title":"Circulating forms of ICAM\u20103 (cICAM\u20103). Elevated levels in autoimmune diseases and lack of association with cICAM\u20101","volume":"154","author":"Martin S","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74603"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441406"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43796"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm831"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3088"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094359"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9765-1"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimcb.12206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:18:25Z","timestamp":1694395105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.12206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/imcb.12206"],"URL":"https:\/\/doi.org\/10.1111\/imcb.12206","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"assertion":[{"value":"2018-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}