{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T15:42:57Z","timestamp":1694533377380},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Brugia malayi<\/jats:italic> is a nematode that causes human lymphatic filariasis. Previously, we showed that mannose\u2010binding lectin (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>)\u2010A is necessary for clearance of <jats:italic>B.\u00a0malayi<\/jats:italic> microfilariae in mice and presence of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010A is linked with maximal levels of parasite\u2010specific IgM. Common human <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> gene polymorphisms result in low <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> expression and lead to recurring bacterial infections. Furthermore, these low\u2010expressing human <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> polymorphisms result in greatly increased susceptibility to lymphatic filarial infection. Indeed, gain of new filarial infections over a 30\u2010year period are 10\u2010fold higher in people with low, compared to high, <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010expression phenotypes. Human <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> closely resembles mouse <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010C, rather than <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010A; therefore, we examined the role of mouse <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010C in clearance of microfilariae. Absence of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010C alone, or both <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010A and \u2010C, resulted in delayed clearance of microfilariae and reduced parasite\u2010specific IgM in mice. There were few profound changes in B cell sub\u2010populations or in the ability of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010deficient mice to respond to T\u2010dependent or T\u2010independent antigens. However, absence of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010A and\/or <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010C resulted in reduced IgM to phosphorylcholine, a constituent of filarial and bacterial antigens, suggesting that inability to form proficient antibody responses to this moiety leads to lack of microfilarial clearance and overall susceptibility to filariasis.<\/jats:p>","DOI":"10.1111\/imcb.12219","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T13:39:32Z","timestamp":1542721172000},"page":"305-316","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decreased nematode clearance and anti\u2010phosphorylcholine\u2010specific IgM responses in mannose\u2010binding lectin\u2010deficient mice"],"prefix":"10.1111","volume":"97","author":[{"given":"Rubina","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences The Royal Veterinary College Royal College Street London NW1 0TU UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma T","family":"Cadman","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences The Royal Veterinary College Royal College Street London NW1 0TU UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford M","family":"Snapper","sequence":"additional","affiliation":[{"name":"Department of Pathology Uniformed Services University of the Health Sciences 4301 Jones Bridge Road Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences The Royal Veterinary College Royal College Street London NW1 0TU UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324264"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0342"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/379324"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00762-08"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082460"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.08.013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2610"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4049\/jimmunol.147.2.692","article-title":"Molecular characterization of the mouse mannose\u2010binding proteins. 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