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The role of <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 is pivotal for T\u2010cell development, with <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1\u2010knockout mice being neonatally lethal, although the exact mechanism is unknown. Moreover, <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 is dysregulated in T\u2010cell lymphoma and proposed to suppress transcription of the <jats:italic>Pdcd1<\/jats:italic> gene, encoding the immune checkpoint programmed cell death protein 1 (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101). Thus, <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 expression in T\u2010cell subsets across different tissue compartments in humans is of potential importance for targeting <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101. Here, we comprehensively analyzed <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 expression across different human tissues and immune compartments by flow cytometry and correlated this with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 expression. We investigated <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 protein levels in pediatric and adult donors and assessed expression dynamics of this chromatin organizer across different immune cell subsets in human organs, as well as in antigen\u2010specific T cells directed against acute and chronic viral infections. Our data demonstrate that <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 expression in humans is the highest in T\u2010cell progenitors in the thymus, and then becomes downregulated in mature T cells in the periphery. Importantly, <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 expression in peripheral mature T cells is not static and follows fine\u2010tuned expression dynamics, which appear to be tissue\u2010 and antigen\u2010dependent. Furthermore, <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 expression negatively correlates with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 expression in virus\u2010specific <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells. Our study has implications for understanding the role of <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>1 in human health and disease and suggests an approach for modulating <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 in T cells, highly relevant to human malignancies or chronic viral infections.<\/jats:p>","DOI":"10.1111\/imcb.12233","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T06:17:55Z","timestamp":1551161875000},"page":"498-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Divergent <scp>SATB<\/scp>1 expression across human life span and tissue compartments"],"prefix":"10.1111","volume":"97","author":[{"given":"Simone","family":"N\u00fcssing","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Melbourne Peter Doherty Institute for Infection and Immunity Parkville VIC 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