{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:02:04Z","timestamp":1789275724742,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Abstract<\/jats:title>\n \n The genomes of classical inbred mouse strains include genes derived from all three major subspecies of the house mouse,\n Mus musculus<\/jats:italic>\n . We recently posited that genetic diversity in the immunoglobulin heavy chain (IGH) gene loci of C57BL\/6 and BALB\/c mice reflects differences in subspecies origin. To investigate this hypothesis, we conducted high\u2010throughput sequencing of\n IGH<\/jats:styled-content>\n gene rearrangements to document\n IGH<\/jats:styled-content>\n variable (\n IGHV<\/jats:styled-content>\n ), joining (\n IGHJ<\/jats:styled-content>\n ) and diversity (\n IGHD<\/jats:styled-content>\n ) genes in four inbred wild\u2010derived mouse strains (\n CAST<\/jats:styled-content>\n \/EiJ,\n LEWES<\/jats:styled-content>\n \/EiJ,\n MSM<\/jats:styled-content>\n \/MsJ and\n PWD<\/jats:styled-content>\n \/PhJ) and a single disease model strain (\n NOD<\/jats:styled-content>\n \/ShiLtJ), collectively representing genetic backgrounds of several major mouse subspecies. A total of 341 germline\n IGHV<\/jats:styled-content>\n sequences were inferred in the wild\u2010derived strains, including 247 not curated in the international ImMunoGeneTics information system. By contrast, 83\/84 inferred\n NOD IGHV<\/jats:styled-content>\n genes had previously been observed in C57\n BL<\/jats:styled-content>\n \/6 mice. Variability among the strains examined was observed for only a single\n IGHJ<\/jats:styled-content>\n gene, involving a description of a novel allele. By contrast, unexpected variation was found in the\n IGHD<\/jats:styled-content>\n gene loci, with four previously unreported\n IGHD<\/jats:styled-content>\n gene sequences being documented. Very few\n IGHV<\/jats:styled-content>\n sequences of C57\n BL<\/jats:styled-content>\n \/6 and\n BALB<\/jats:styled-content>\n \/c mice were shared with strains representing major subspecies, suggesting that their\n IGH<\/jats:styled-content>\n loci may be complex mosaics of genes of disparate origins. This suggests a similar level of diversity is likely present in the\n IGH<\/jats:styled-content>\n loci of other classical inbred strains. This must now be documented if we are to properly understand interstrain variation in models of antibody\u2010mediated disease.\n <\/jats:p>","DOI":"10.1111\/imcb.12288","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T03:34:53Z","timestamp":1566531293000},"page":"888-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A comparison of immunoglobulin\n IGHV<\/scp>\n ,\n IGHD<\/scp>\n and\n IGHJ<\/scp>\n genes in wild\u2010derived and classical inbred mouse strains"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-8787","authenticated-orcid":false,"given":"Corey T","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics University of Louisville School of Medicine Louisville KY 40202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin 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