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Effective vaccination against murid herpesvirus\u20104 (MuHV\u20104)\u2010driven lymphoproliferation by latency\u2010impaired mutant viruses suggests that lytic access to the latency reservoir is a viable target for control. However, the vaccines retained the immunogenic Mu<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 <jats:italic>M2<\/jats:italic> latency gene. Here, a strong reduction in challenge virus load was maintained when the challenge virus lacked the main latency\u2010associated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T\u2010cell epitope of <jats:italic>M2<\/jats:italic>, or when the vaccine virus lacked <jats:italic>M2<\/jats:italic> entirely. This protection was maintained also when the vaccine virus lacked both episome maintenance and the genomic region encompassing <jats:italic>M1<\/jats:italic>,<jats:italic> M2<\/jats:italic>,<jats:italic> M3<\/jats:italic>,<jats:italic> M4<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ORF<\/jats:styled-content>4<\/jats:italic>. Therefore, protection did not require immunity to known Mu<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 latency genes. As the remaining vaccine virus genes have clear homologs in human \u03b3\u2010herpesviruses, this approach of deleting viral latency genes could also\u00a0be applied to them, to generate safe and effective vaccines against human\u00a0disease.<\/jats:p>","DOI":"10.1111\/imcb.12299","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T04:53:51Z","timestamp":1571547231000},"page":"67-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vaccine protection against murid herpesvirus\u20104 is maintained when the priming virus lacks known latency genes"],"prefix":"10.1111","volume":"98","author":[{"given":"Clara","family":"Lawler","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o 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