{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:47:53Z","timestamp":1785800873743,"version":"3.56.0"},"reference-count":104,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2018\/05181\u20107"],"award-info":[{"award-number":["#2018\/05181\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanisms by which immunoglobulin (Ig)G can modulate immunity have been investigated over the past few decades. In the past three years, some studies have demonstrated that IgG can play a pivotal role in mediating complex interactions that result in functional lymphocyte modulation during maturation in self or offspring primary lymphoid organs. This effect appears to be dependent on the IgG repertoire in the absence of the influence of antigens and the functionality of diverse cell populations, including B, \u03b1\u03b2T (CD4 T and CD8 T), invariant natural killer T and \u03b3\u03b4T cells, in mice and humans. Based on the literature, especially on findings resulting from the therapeutic use of purified IgG (intravenous Ig) and recent pieces of evidence obtained by my group, the \u201chooks without bait\u201d theory is described here to guide the future development of therapies for specific immune regulation.<\/jats:p>","DOI":"10.1111\/imcb.12335","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T08:37:59Z","timestamp":1588063079000},"page":"540-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Do different IgG repertoires play a role in B\u2010 and T\u2010cell functional modulation during ontogeny? The \u201chooks without bait\u201d theory"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6092-8394","authenticated-orcid":false,"given":"Jefferson R","family":"Victor","sequence":"first","affiliation":[{"name":"Laboratory of Medical Investigation LIM 56 Division of Clinical Dermatology Medical School University of Sao Paulo Sao Paulo Brazil"},{"name":"Division of Environmental Health FMU Laureate International Universities Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.39"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-11-11"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.01.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02618.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053865"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03028.x"},{"key":"e_1_2_8_8_1","first-page":"10","article-title":"Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on Fc\u03b3RIIb expression on offspring B cells","author":"Lima Lira AA","year":"2014","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/1750743X.1.1.141"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9358-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01429.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-2821-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2005.08.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/780386"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02615.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02111.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00771.x"},{"key":"e_1_2_8_18_1","first-page":"49","volume":"48","author":"Jarrett EE","year":"1983","journal-title":"IgE suppression by maternal IgG. Immunology"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00028-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4138::AID-IMMU4138>3.0.CO;2-L"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199807)28:07<2124::AID-IMMU2124>3.0.CO;2-A"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1984.tb00484.x"},{"key":"e_1_2_8_23_1","first-page":"487","article-title":"Cellular sites of immunoglobulins. I. Distribution of light polypeptide chains in human lymphoid tissue","volume":"20","author":"Chen ST","year":"1970","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_8_24_1","first-page":"85","article-title":"Cellular sites of immunoglobulins. III. Localization of IgG\u2010, IgA\u2010, IgM\u2010 and their kappa and lambda light chain\u2010containing cells in human palatine tonsils","volume":"21","author":"Chen ST","year":"1971","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_8_25_1","first-page":"67","article-title":"Cellular sites of immunoglobulins. II. The relative proportions of mucosal cells containing IgG, IgA, and IgM, and light polypeptide chains of kappa and lambda immunoglobulin in human appendices","volume":"21","author":"Chen ST","year":"1971","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_8_26_1","first-page":"69","article-title":"Cellular sites of immunoglobulins. VI. Localization of immunoglobulins in the human thymus","volume":"25","author":"Chen ST","year":"1975","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3181e61ebf"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-019-0393-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1996.d01-724.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830160921"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05664.x"},{"key":"e_1_2_8_32_1","first-page":"414","article-title":"Immunoregulation by processed immunoglobulin on B\u2010cells","volume":"30","author":"Ghosh SK","year":"1993","journal-title":"Indian J Biochem Biophys"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2427-4_14"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v27.i3.30"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.05.017"},{"key":"e_1_2_8_36_1","first-page":"193","article-title":"Natural autoantibodies to TCR public idiotopes: potential roles in immunomodulation","volume":"49","author":"Schluter SF","year":"2003","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010grand)"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx039"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317696589"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.07.046"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.04.012"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.04.011"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1423.072"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01129.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00712.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00344.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.01.002"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20609"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181dd6bf1"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00335.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90612-B"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450110068029"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520480053039"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90420-S"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03377.x"},{"key":"e_1_2_8_55_1","first-page":"139","article-title":"High doses intravenous immunoglobulin versus oral cyclosporine in the treatment of severe atopic dermatitis","volume":"4","author":"Bemanian MH","year":"2005","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13295"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3401"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061788"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154315"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129594"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.015"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00011"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199306000-00010"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-415695"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301611"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5503.484"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.02.006"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4024"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.014"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12022"},{"key":"e_1_2_8_71_1","first-page":"4","article-title":"A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity.","author":"Zhang X","year":"2019","journal-title":"JCI Insight"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92000-J"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037243"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000116"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90701-3"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-586-6_18"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm052"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116291"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2020.1713153"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.064"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01669"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30464"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02579.x"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:29:3:213"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2019.1572411"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2015.18"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1244592"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-017-0195-8"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1299299"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13907"},{"key":"e_1_2_8_91_1","article-title":"IgG from atopic dermatitis patients induces non\u2010atopic infant thymic invariant natural killer T (iNKT) cells to produce IL\u20104, IL\u201017, and IL\u201010","author":"Santos LS","year":"2019","journal-title":"Int J Dermatol"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002182"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13393"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-019-00545-6"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.07.009"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2016.121"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12482"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-016-0272-7"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx025"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201017666161029225929"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx053"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001816"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0019-2"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/334395a0"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00462"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimcb.12335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imcb.12335","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:25:59Z","timestamp":1693895159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.12335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":104,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/imcb.12335"],"URL":"https:\/\/doi.org\/10.1111\/imcb.12335","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]},"assertion":[{"value":"2019-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}