{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:07:48Z","timestamp":1760609268993},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10 OD021676","AI\u201055563","DE\u2010026450"],"award-info":[{"award-number":["1S10 OD021676","AI\u201055563","DE\u2010026450"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Understanding the migration of lymphocytes to nonintestinal mucosal sites is fundamental to developing mucosal vaccination strategies. Studies have shown that nasal and oral immunization with cholera toxin (CT) stimulates, in addition to \u03b14\u03b27<jats:sup>+<\/jats:sup>, the induction of \u03b1E (CD103)\u03b27<jats:sup>+<\/jats:sup> B cells. To determine the extent to which \u03b1E\u2010associated \u03b27 contributes to antigen (Ag)\u2010specific immunoglobulin (Ig)A responses in the upper respiratory tract, nasal CT vaccination was performed in wild\u2010type (wt) and \u03b27<jats:sup>\u2212\/\u2212<\/jats:sup> mice. At 16\u00a0days postprimary immunization, upper respiratory tract IgA responses were greater in \u03b27<jats:sup>\u2212\/\u2212<\/jats:sup> mice than in wt mice. IgA induction by distal \u03b27<jats:sup>\u2212\/\u2212<\/jats:sup> Peyer\u2019s patches, mesenteric lymph nodes and small intestinal lamina propria was minimal, in contrast to elevated gut IgA responses in wt mice. By 42\u00a0days postprimary immunization, \u03b27<jats:sup>\u2212\/\u2212<\/jats:sup> gut IgA responses were restored, and upper respiratory tract Ag\u2010specific IgA responses were equivalent to those of wt mice. Examination of homing receptor expression and cell\u2010sorting experiments revealed that \u03b27<jats:sup>\u2212\/\u2212<\/jats:sup> mice have increased usage of \u03b21 and \u03b1E integrins by upper respiratory tract B cells, suggesting that alternative integrins can facilitate lymphocyte migration to the upper respiratory tract, especially in the absence of \u03b27.<\/jats:p>","DOI":"10.1111\/imcb.12364","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T20:45:08Z","timestamp":1591044308000},"page":"667-681","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nasal vaccination of \u03b27 integrin\u2010deficient mice retains elevated IgA immunity"],"prefix":"10.1111","volume":"98","author":[{"given":"Tomasz","family":"Ma\u015blanka","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Warmia and Mazury Olsztyn 10\u2010718 Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Clapp","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases &amp; Immunology College of Veterinary Medicine University of Florida Gainesville FL 32611\u20100880 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases &amp; Immunology College of Veterinary Medicine University of Florida Gainesville FL 32611\u20100880 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Montana State University Bozeman MT 59715 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Gregorczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Warmia and Mazury Olsztyn 10\u2010718 Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases &amp; Immunology College of Veterinary Medicine University of Florida Gainesville FL 32611\u20100880 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"39","article-title":"M cell\u2010targeted mucosal vaccine strategies","volume":"354","author":"Yamamoto M","year":"2012","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.07.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02319.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1783OC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.4049\/jimmunol.163.3.1382","article-title":"Nasal\u2010associated lymphoid tissue: phenotypic and functional evidence for the primary role of peripheral node addressin in naive lymphocyte adhesion to high endothelial venules in a mucosal site","volume":"163","author":"Csencsits KL","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200211)32:11<3029::AID-IMMU3029>3.0.CO;2-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.7.2676-2684.1997"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.08.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90981-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652409789105525"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90305-A"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/366695a0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.152.7.3282"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2441"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.10.5649"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2007.2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1996.d01-727.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119286"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03709.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2007.14"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44262"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/372190a0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250333"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.4049\/jimmunol.162.11.6641","article-title":"Mucosal T lymphocyte numbers are selectively reduced in integrin \u03b1E (CD103)\u2010deficient mice","volume":"162","author":"Sch\u00f6n MP","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/382366a0"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.8.3459"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.1.197"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3506"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03352.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.4049\/jimmunol.161.8.4227","article-title":"The memory B cell subset responsible for the secretory IgA response and protective humoral immunity to rotavirus expresses the intestinal homing receptor, \u03b14\u03b27","volume":"161","author":"Williams MB","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1894"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202979"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv208"},{"key":"e_1_2_7_36_1","first-page":"1371","article-title":"Immune defense in upper airways: a single\u2010cell study of pathogen\u2010specific plasmablasts and their migratory potentials in acute sinusitis and tonsillitis","volume":"10","author":"Palkola NV","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.4049\/jimmunol.161.12.6638","article-title":"Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L\u2010selectin and \u03b27 integrin","volume":"161","author":"Steeber DA","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.10.1631"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3832::AID-IMMU3832>3.0.CO;2-J"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902407"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002053"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2006.11.008"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4630"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.04.017"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059822"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.4049\/jimmunol.160.3.1198","article-title":"Cholera toxin and cholera toxin B subunit induce IgA switching through the action of TGF\u2010\u00df1","volume":"160","author":"Kim PH","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.42"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.7492"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imcb.12364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:49:29Z","timestamp":1693957769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.12364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/imcb.12364"],"URL":"https:\/\/doi.org\/10.1111\/imcb.12364","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,8]]},"assertion":[{"value":"2019-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}