{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:54:23Z","timestamp":1787241263859,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773741"],"award-info":[{"award-number":["81773741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973329"],"award-info":[{"award-number":["81973329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770633"],"award-info":[{"award-number":["81770633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Serum amyloid A (SAA) is an early and sensitive biomarker of inflammatory diseases, but its role in acute pancreatitis (AP) is still unclear. Here, we used a caerulein\u2010induced mouse model to investigate the role of SAA in AP and other related inflammatory responses. In our study, we found that the expression of a specific SAA isoform, SAA3, was significantly elevated in a caerulein\u2010induced AP animal model. In addition, SAA3\u2010knockout (\n                    <jats:italic>Saa3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice showed lower serum levels of amylase and lipase, tissue damage and proinflammatory cytokine production in the pancreas compared with those of wild\u2010type mice in response to caerulein administration. AP\u2010associated acute lung injury was also significantly attenuated in\n                    <jats:italic>Saa3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. In our\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments, treatment with cholecystokinin and recombinant SAA3 significantly induced necroptosis and cytokine production. Moreover, we found that the regulatory effect of SAA3 on acinar cell necroptosis was through a receptor\u2010interacting protein 3 (RIP3)\u2010dependent manner. Collectively, our findings indicate that SAA3 is required for AP by inducing an RIP3\u2010dependent necroptosis pathway in acinar cells and is a potential drug target for AP.\n                  <\/jats:p>","DOI":"10.1111\/imcb.12382","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T22:06:57Z","timestamp":1595974017000},"page":"34-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Serum amyloid A3 is required for caerulein\u2010induced acute pancreatitis through induction of RIP3\u2010dependent necroptosis"],"prefix":"10.1111","volume":"99","author":[{"given":"Xinyi","family":"Yang","sequence":"first","affiliation":[{"name":"Engineering Research Center of Cell &amp; Therapeutic Antibody Ministry of Education School of Pharmacy Shanghai Jiao Tong University Shanghai 200240 PR 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