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The leading cause of death among COVID\u201019 patients is acute respiratory distress syndrome caused by hyperinflammation secondary to cytokine release syndrome (CRS). Cytokines, such as tumor necrosis factor\u2010\u03b1, interleukin\u20106, interferon\u2010\u03b3 and interleukin\u201010, are the main mediators of CRS. Based on recent evidence, the angiotensin\u2010converting enzyme (ACE) II is known to be the target of the COVID\u201019 spike protein, which enables the virus to penetrate human cells. ACE II also possesses an anti\u2010inflammatory role in many pathologies such as cardiovascular disease, hypertension, diabetes mellitus and other conditions, which are the main risk factors of poor prognosis in COVID\u201019 infection. Changes in tissue ACE II levels are associated with many diseases and hyperinflammatory states, and it is assumed that elevated levels of ACE II could aggravate the course of COVID\u201019 infection. Therefore, the use of renin\u2013angiotensin\u2013aldosterone system inhibitors (RASis) in COVID\u201019 patients could be hypothetically considered, though sufficient evidence is not presented by the scientific community. In this work, based on the most recent pieces of evidence, the roles of RAS and RASi in immunologic interactions are addressed. Furthermore, the molecular and immunologic aspects of RASi and their potential significance in COVID\u201019 are discussed.<\/jats:p>","DOI":"10.1111\/imcb.12396","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T05:59:16Z","timestamp":1598853556000},"page":"192-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin\u2010converting enzyme as a new immunologic target for the new SARS\u2010CoV\u20102"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-1915","authenticated-orcid":false,"given":"Shahin","family":"Hallaj","sequence":"first","affiliation":[{"name":"Department of Basic Science Faculty of Medicine Maragheh University of Medical Sciences Maragheh Iran"},{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-7520","authenticated-orcid":false,"given":"Anahita","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"Department of Basic Science Faculty of Medicine Maragheh University of Medical Sciences Maragheh Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ali","family":"Mousavi\u2010Aghdas","sequence":"additional","affiliation":[{"name":"Department of Basic Science Faculty of Medicine Maragheh University of Medical Sciences Maragheh Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Mirza\u2010Aghazadeh\u2010Attari","sequence":"additional","affiliation":[{"name":"Department of Basic Science Faculty of Medicine Maragheh University of Medical Sciences Maragheh Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Sevbitov","sequence":"additional","affiliation":[{"name":"Head of Department of Propaedeutics of Dental Diseases I.M. 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