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Cell Biol."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The stress\u2010activated protein kinases (SAPKs)\/c\u2010Jun\u2010N\u2010terminal\u2010kinases (JNK) are members of the mitogen\u2010activated protein kinase family. These kinases are responsible for transducing cellular signals through a phosphorylation\u2010dependent signaling cascade. JNK activation in immune cells can lead to a range of critical cellular responses that include proliferation, differentiation and apoptosis. MKK4 is a SAPK that can activate both JNK1 and JNK2; however, its role in T\u2010cell development and function has been controversial. Additionally, loss of either JNK1 or JNK2 has opposing effects in the generation of T\u2010cell immunity to viral infection and cancer. We used mice with a conditional loss of MKK4 in T cells to investigate the <jats:italic>in vivo<\/jats:italic> role of MKK4 in T\u2010cell development and function during lymphocytic choriomeningitis virus (LCMV) infection. We found no physiologically relevant differences in T\u2010cell responses or immunity to either acute or chronic LCMV in the absence of MKK4.<\/jats:p>","DOI":"10.1111\/imcb.12426","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T15:11:00Z","timestamp":1605107460000},"page":"428-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The role of MKK4 in T\u2010cell development and immunity to viral infections"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-8297","authenticated-orcid":false,"given":"Simon P","family":"Preston","sequence":"first","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research Parkville VIC Australia"},{"name":"Department of Medical Biology The University of Melbourne Parkville VIC 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