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To identify differences in TCR signal strength that accompany thymic selection and peripheral T\u2010cell maintenance, we compared CD5 levels, a marker of basal TCR signal strength, on immature and mature T cells from autoimmune diabetes\u2010prone NOD and \u2010resistant B6 mice. The data suggest that there is no preferential selection of NOD thymocytes that perceive stronger TCR signals from self\u2010peptide engagement. Instead, NOD mice have an MHC\u2010dependent increase in CD4<jats:sup>+<\/jats:sup> thymocytes and mature T cells that express lower levels of CD5. In contrast, T cell\u2010intrinsic mechanisms lead to higher levels of CD5 on peripheral CD8<jats:sup>+<\/jats:sup> T cells from NOD relative to B6 mice, suggesting that peripheral CD8<jats:sup>+<\/jats:sup> T cells with higher basal TCR signals may have survival advantages in NOD mice. These differences in the T\u2010cell pool in NOD mice may contribute to the development or progression of autoimmune diabetes.<\/jats:p>","DOI":"10.1111\/imcb.12443","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T02:15:34Z","timestamp":1612577734000},"page":"656-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CD5 levels reveal distinct basal T\u2010cell receptor signals in T cells from non\u2010obese diabetic mice"],"prefix":"10.1111","volume":"99","author":[{"given":"Mengqi","family":"Dong","sequence":"first","affiliation":[{"name":"Immunology\u2010Oncology Unit Maisonneuve\u2010Rosemont Hospital Research Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement de microbiologie, Infectiologie et Immunologie Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec 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