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However, BALB\/c mice developed much greater inflammatory responses than C57BL\/6 mice, effects possibly explained by a failure to induce pathways that regulate and maintain T\u2010cell activation in C57BL\/6 mice, as shown by whole lung RNA transcript analysis. Allergen administration resulted in a similar degree of airway remodeling between mouse strains but with differences in collagen subtype composition. Increased collagen III was observed around the airways of C57BL\/6 but not BALB\/c mice while allergen\u2010induced loss of basement membrane collagen IV was only observed in BALB\/c mice. This study highlights a model of type 2\/type 17 airway inflammation in mice whereby development of airway remodeling can occur in both BALB\/c and C57BL\/6 mice despite differences in immune response dynamics between strains. Importantly, compositional changes in the extracellular matrix between genetic strains of mice may help us better understand the relationships between lung function, remodeling and airway inflammation.<\/jats:p>","DOI":"10.1111\/imcb.12448","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T14:39:12Z","timestamp":1613399952000},"page":"640-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The magnitude of airway remodeling is not altered by distinct allergic inflammatory responses in BALB\/c\n                    <i>versus<\/i>\n                    C57BL\/6 mice but matrix composition differs"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-5121","authenticated-orcid":false,"given":"James E","family":"Parkinson","sequence":"first","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"},{"name":"Wellcome Centre for Cell\u2010Matrix Research Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Pearson","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"},{"name":"Wellcome Centre for Cell\u2010Matrix Research Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-1451","authenticated-orcid":false,"given":"Dominik","family":"R\u00fcckerl","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-066X","authenticated-orcid":false,"given":"Judith E","family":"Allen","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"},{"name":"Wellcome Centre for Cell\u2010Matrix Research Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-8206","authenticated-orcid":false,"given":"Tara E","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"},{"name":"Wellcome Centre for Cell\u2010Matrix Research Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"The Global Asthma Report Auckland New Zealand. 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