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CXCR3 binds three chemokine ligands, CXCL9, CXCL10 and CXCL11. These ligands display distinct expression patterns and ligand signaling biases; however, how each ligand functions individually and collaboratively is incompletely understood. CXCL9 and CXCL10 are considered pro\u2010inflammatory chemokines during viral infection, while CXCL11 may induce a tolerizing state. The investigation of the individual role of CXCL11 <jats:italic>in\u2009vivo<\/jats:italic> has been hampered as C57BL\/6 mice carry several mutations that result in a null allele. Here, CRISPR\/Cas9 was used to correct these mutations on a C57BL\/6 background. It was validated that CXCL11<jats:sup>KI<\/jats:sup> mice expressed CXCL11 protein in dendritic cells, spleen and lung. CXCL11<jats:sup>KI<\/jats:sup> mice were largely phenotypically indistinguishable from C57BL\/6 mice, both at steady\u2010state and during two models of viral infection. 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