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Mouse MAIT cells egress from the thymus as two main subpopulations with distinct functions, namely, T\u2010bet\u2010expressing MAIT1 and ROR\u03b3t\u2010expressing MAIT17 cells. Previously, we reported that inducible T\u2010cell costimulator and interleukin (IL)\u201023 provide essential signals for optimal MHC\u2010related protein 1 (MR1)\u2010dependent activation and expansion of MAIT17 cells\n in\u2009vivo<\/jats:italic>\n . Here, in a model of tularemia, in which MAIT1 responses predominate, we demonstrate that IL\u201012 and IL\u201023 promote MAIT1 cell expansion during acute infection and that IL\u201012 is indispensable for MAIT1 phenotype and function. Furthermore, we showed that the bias toward MAIT1 or MAIT17 responses we observed during different bacterial infections was determined and modulated by the balance between IL\u201012 and IL\u201023 and that these responses could be recapitulated by cytokine coadministration with antigen. Our results indicate a potential for tailored immunotherapeutic interventions via MAIT cell manipulation.\n <\/jats:p>","DOI":"10.1111\/imcb.12556","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T03:13:32Z","timestamp":1651806812000},"page":"547-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The balance of interleukin\u201012 and interleukin\u201023 determines the bias of MAIT1\n versus<\/i>\n MAIT17 responses during bacterial infection"],"prefix":"10.1111","volume":"100","author":[{"given":"Huimeng","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease Guangzhou Medical University Guangzhou China"},{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity The University of Melbourne Melbourne VIC 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