{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:52:09Z","timestamp":1792378329505,"version":"4.4.0"},"reference-count":116,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age can profoundly affect susceptibility to a broad range of human diseases. Children are more susceptible to some infectious diseases such as diphtheria and pertussis, while in others, such as coronavirus disease 2019 and hepatitis A, they are more protected compared with adults. One explanation is that the composition of the immune system is a major contributing factor to disease susceptibility and severity. While most studies of the human immune system have focused on adults, how the immune system changes after birth remains poorly understood. Here, using high\u2010dimensional spectral flow cytometry and computational methods for data integration, we analyzed more than 50 populations of immune cells in the peripheral blood, generating an immune cell atlas that defines the healthy human immune system from birth up to 75\u2009years of age. We focused our efforts on children under 18\u2009years old, revealing major changes in immune cell populations after birth and in children of schooling age. Specifically, CD4<jats:sup>+<\/jats:sup> T effector memory cells, V\u03b42<jats:sup>+<\/jats:sup> gamma delta (\u03b3\u03b4)T cells, memory B cells, plasmablasts, CD11c<jats:sup>+<\/jats:sup> B cells and CD16<jats:sup>+<\/jats:sup>CD56<jats:sup>bright<\/jats:sup> natural killer (NK) cells peaked in children aged 5\u20139\u2009years old, whereas frequencies of T helper 1, T helper 17, dendritic cells and CD16<jats:sup>+<\/jats:sup>CD57<jats:sup>+<\/jats:sup>CD56<jats:sup>dim<\/jats:sup> NK cells were highest in older children (10\u201318\u2009years old). The frequency of mucosal\u2010associated invariant T cells was low in the first several years of life and highest in adults between 19 and 30\u2009years old. Late adulthood was associated with fewer mucosal\u2010associated invariant T cells and V\u03b42<jats:sup>+<\/jats:sup> \u03b3\u03b4\u00a0T cells but with increased frequencies of memory subsets of B cells, CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells and CD57<jats:sup>+<\/jats:sup> NK cells. This human immune cell atlas provides a critical resource to understand changes to the immune system during life and provides a reference for investigating the immune system in the context of human disease. This work may also help guide future therapies that target specific populations of immune cells to protect at\u2010risk populations.<\/jats:p>","DOI":"10.1111\/imcb.12594","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T09:34:30Z","timestamp":1665480870000},"page":"805-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["A high\u2010dimensional cytometry atlas of peripheral blood over the human life span"],"prefix":"10.1111","volume":"100","author":[{"given":"Sedigheh","family":"Jalali","sequence":"first","affiliation":[{"name":"Murdoch Children's Research Institute  Melbourne VIC Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Harpur","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Melbourne VIC 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P","family":"Berzins","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity University of Melbourne  Melbourne VIC Australia"},{"name":"The Fiona Elsey Cancer Research Institute  Ballarat VIC Australia"},{"name":"Federation University  Ballarat VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul V","family":"Licciardi","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Melbourne VIC Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-7773","authenticated-orcid":false,"given":"Thomas M","family":"Ashhurst","sequence":"additional","affiliation":[{"name":"Sydney Cytometry Core Research Facility The University of Sydney and Centenary Institute  Sydney NSW Australia"},{"name":"School of Medical 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