{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:32:16Z","timestamp":1790433136713,"version":"4.1.0"},"reference-count":89,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chemokine (C\u2013C) ligand 17 (CCL17) was first identified as thymus\u2010 and activation\u2010regulated chemokine when it was found to be constitutively expressed in the thymus and identified as a T\u2010cell chemokine. This chemoattractant molecule has subsequently been found at elevated levels in a range of autoimmune and inflammatory diseases, as well as in cancer. CCL17 is a C\u2013C chemokine receptor type 4 (CCR4) ligand, with chemokine (C\u2013C) ligand 22 being the other major ligand and, as CCR4 is highly expressed on helper T cells, CCL17 can play a role in T\u2010cell\u2013driven diseases, usually considered to be\n                    <jats:italic>via<\/jats:italic>\n                    its chemotactic activity on T helper 2 cells; however, given that CCR4 is also expressed by other cell types and there is elevated expression of CCL17 in many diseases, a broader CCL17 biology is suggested. In this review, we summarize the biology of CCL17, its regulation and its potential contribution to the pathogenesis of various preclinical models. Reference is made, for example, to recent literature indicating a role for CCL17 in the control of pain as part of a granulocyte macrophage\u2013colony\u2010stimulating factor\/CCL17 pathway in lymphocyte\u2010independent models and thus not as a T\u2010cell chemokine. The review also discusses the potential for CCL17 to be a biomarker and a therapeutic target in human disorders.\n                  <\/jats:p>","DOI":"10.1111\/imcb.12644","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T07:35:51Z","timestamp":1679988951000},"page":"600-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["<scp>CCL17<\/scp>\n                    \/\n                    <scp>TARC<\/scp>\n                    in autoimmunity and inflammation\u2014not just a T\u2010cell chemokine"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-8593","authenticated-orcid":false,"given":"Tanya J","family":"Lupancu","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Melbourne Hospital The University of Melbourne  Parkville VIC 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