{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:03:01Z","timestamp":1790866981996,"version":"4.1.0"},"reference-count":218,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dysregulation of innate immune responses can result in chronic inflammatory conditions. Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but come with a trade\u2010off of cumulative and serious side effects. Therefore, alternative drug options with improved safety profiles are urgently needed. Sulforaphane, a phytochemical derived from plants of the brassica family, is a potent inducer of phase II detoxification enzymes<jats:italic>via<\/jats:italic>nuclear factor\u2010erythroid factor 2\u2013related factor 2 (NRF2) signaling. Moreover, a growing body of evidence suggests additional diverse anti\u2010inflammatory properties of sulforaphane through interactions with mediators of key signaling pathways and inflammatory cytokines. Multiple studies support a role for sulforaphane as a negative regulator of nuclear factor kappa\u2010light chain enhancer of activated B cells (NF\u2010\u03baB) activation and subsequent cytokine release, inflammasome activation and direct regulation of the activity of macrophage migration inhibitory factor. Significantly, studies have also highlighted potential steroid\u2010sparing activity for sulforaphane, suggesting that it may have potential as an adjunctive therapy for some inflammatory conditions. This review discusses published research on sulforaphane, including proposed mechanisms of action, and poses questions for future studies that might help progress our understanding of the potential clinical applications of this intriguing molecule.<\/jats:p>","DOI":"10.1111\/imcb.12686","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:39:36Z","timestamp":1693481976000},"page":"805-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Exploring the anti\u2010inflammatory activity of sulforaphane"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2183-9684","authenticated-orcid":false,"given":"Katie","family":"Treasure","sequence":"first","affiliation":[{"name":"Department of Nutrition, Dietetics and Food, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences Monash University Clayton VIC Australia"},{"name":"Victorian Heart Hospital, Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-9637","authenticated-orcid":false,"given":"James","family":"Harris","sequence":"additional","affiliation":[{"name":"Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation (CSIRO) Clayton VIC Australia"},{"name":"Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5624-6267","authenticated-orcid":false,"given":"Gary","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics and Food, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences Monash University Clayton VIC Australia"},{"name":"Victorian Heart Hospital, Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.767221"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez387"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3180-y"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.03.002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00440-y"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.39"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2015.1099409"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.04.005"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01684"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1033"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.01.003"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1461-3"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00297-8"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311402246"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.109830"},{"key":"e_1_2_13_17_1","first-page":"49","article-title":"Pancreas cancer and smoking, beverage consumption, and past medical history","volume":"76","author":"Mack TM","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9454-4"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635588809513983"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy082"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200201)46:1<83::AID-ART10042>3.0.CO;2-D"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh296"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050623"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5460302"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12278"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665108008884"},{"key":"e_1_2_13_27_1","first-page":"1091","article-title":"Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables","volume":"7","author":"Shapiro TA","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.01.002"},{"key":"e_1_2_13_29_1","first-page":"501","article-title":"Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans","volume":"10","author":"Shapiro TA","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7857186"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2021.10.014"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1326"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004104107"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110244200"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200225"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300894"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700980"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC382_5"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf801989e"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507381403"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.02.004"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518002921"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc5501_7"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.6.1283"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00722"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/02772248.2010.494828"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.10.400"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.15.2"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7176"},{"key":"e_1_2_13_51_1","first-page":"7520","article-title":"Effects of glutathione on antioxidant response element\u2010mediated gene expression and apoptosis elicited by sulforaphane","volume":"63","author":"Kim BR","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.6.1175"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1601"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092980"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07032"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487639"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00085"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx0502138"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.10.007"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2016.07.007"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4002"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421146"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx177"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25790"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6968"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503346200"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.6.2399"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10367"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1039-5"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.655019"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.09.065"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.08.190"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114186"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104794200"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390407"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.4.477"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.016"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00312-6"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2007.11.006"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.12.037"},{"key":"e_1_2_13_83_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1016-8478(23)13240-7","article-title":"Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor\u2010\u03baB","volume":"20","author":"Kim SJ","year":"2005","journal-title":"Mol Cells"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3562"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300063"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.06.034"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208656"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.07.025"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7574"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.03.002"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1413-8"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6615"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01487"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12618"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0160-9"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124223"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12285"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.987453"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-013-9881-6"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.929162"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016814108"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86953"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3089"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.2147\/OARRR.S151013"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0415-155RR"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2021.03.004"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex499"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.01.034"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100613"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1895"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1524"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04581-2"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12376"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030286"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.277"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-10-0288"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-273904"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01273"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-016-0138-6"},{"key":"e_1_2_13_121_1","first-page":"2760","article-title":"Pleiotropic role of macrophage migration inhibitory factor in cancer","volume":"9","author":"Guda MR","year":"2019","journal-title":"Am J Cancer Res"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00796.x"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076206"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5687"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29909"},{"key":"e_1_2_13_126_1","first-page":"397","article-title":"Quantitation of macrophage migration inhibitory factor (MIF) using the one\u2010step sandwich enzyme immunosorbent assay: elevated serum MIF concentrations in patients with autoimmune diseases and identification of MIF in erythrocytes","volume":"5","author":"Mizue Y","year":"2000","journal-title":"Int J Mol Med"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01261-1"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0279"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2019.1656718"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.1864"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091170"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi3005494"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2016.1251582"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203220200"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102941108"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.03.014"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-256636"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.047092"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00859-z"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107555"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40672"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0291OC"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-022-00668-0"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.06.013"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002537"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.113332"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0494"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02834.x"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105396"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.09.007"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10101466"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.275495"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00465.2017"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114055"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2018.78697"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0119"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400674"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1619783"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004974"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1992.tb137299.x"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.743328"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2021-218555"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146102"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535413"},{"key":"e_1_2_13_165_1","first-page":"1455","article-title":"MIF attenuates the suppressive effect of dexamethasone on IL\u20106 production by nasal polyp","volume":"17","author":"Stathas T","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.3.R1043"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38689"},{"key":"e_1_2_13_168_1","first-page":"775","article-title":"Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o\u2010JIA): association of MIF promoter polymorphisms with response to intra\u2010articular glucocorticoids","volume":"25","author":"Vivarelli M","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_13_169_1","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519893870","article-title":"Correlations of MIF polymorphism and serum levels of MIF with glucocorticoid sensitivity of sudden sensorineural hearing loss","volume":"48","author":"Zhu WY","year":"2020","journal-title":"J Int Med Res"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/377068a0"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S65410"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.05.026"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041337"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00134006"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0065"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02006.x"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00235-1"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163716"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.02.004"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0253-z"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0192"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3FO60277J"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0290"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i43.12457"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201801029"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0406-8"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152895"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163263"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-021-00447-5"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700911"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416940111"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13276"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2019.139"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf201501x"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020352"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.10.029"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2021.03.018"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111266"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511004429"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13016"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-14-0103"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr229"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03629-5"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.03.012"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-14-0459"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14040"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz012"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-17-0268"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.7.1718"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030718"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0368"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002568"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz122"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-018-0218-4"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147742"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.009"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000037792.04787.8a"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400863"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2012.665043"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T07:34:43Z","timestamp":1730014483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.12686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":218,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/imcb.12686"],"URL":"https:\/\/doi.org\/10.1111\/imcb.12686","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]},"assertion":[{"value":"2023-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}