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Their reactivity to self\u2010antigens and ability to secrete various cytokines make them a key component in psoriasis development. Although the correlation between the immune repertoire (IR) of \u03b3\u03b4 T\u2010cell receptors and the occurrence and severity of psoriasis remains incompletely explored, high\u2010throughput sequencing of \u03b3\u03b4 T\u00a0cells has led to a deeper understanding of IR in psoriasis. This study investigated the differences between \u03b3\u03b4 T\u00a0cells in patients with psoriasis and healthy controls. The \u03b3\u03b4 T\u00a0cells were identified <jats:italic>via<\/jats:italic> immunofluorescence staining and a correlation analysis was performed according to the psoriasis area and severity index (PASI) scores. The IR sequencing method was used to detect IR in the \u03b3\u03b4 T\u2010cell receptors. The findings demonstrated more skin \u03b3\u03b4 T\u00a0cells in patients with psoriasis, which were positively correlated with the PASI score. There were subtle differences in most variable (V), diversity (D) and joining (J) gene segments and VJ\/VDJ combination segments between patients with psoriasis and healthy controls. However, a higher diversity of complementarity\u2010determining region 3 (CDR3) was observed in patients with psoriasis. In summary, the IR of skin \u03b3\u03b4 T\u00a0cells was significantly altered in patients with psoriasis, and the diversity in the cell's CDR3 population is a promising biomarker for assessment of psoriasis severity.<\/jats:p>","DOI":"10.1111\/imcb.12765","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T01:20:05Z","timestamp":1715044805000},"page":"570-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of the immune repertoire of \u03b3\u03b4 T\u2010cell receptors in psoriasis"],"prefix":"10.1111","volume":"102","author":[{"given":"Yuting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Zhongshan Hospital (Xiamen) Fudan University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanze","family":"Fu","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, The First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinjiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, The First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, The First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zhongshan Hospital (Xiamen) Fudan University  Xiamen Fujian China"},{"name":"Department of Dermatology Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, The First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejia","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, The First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zhongshan Hospital (Xiamen) Fudan University  Xiamen Fujian China"},{"name":"Department of Dermatology Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"HoltmeierW KabelitzD.Focus on human V\u03b39\/V\u03b42 and V\u03b41 T\u00a0cells."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120216"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.198"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12495"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.2019940211"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abi8823"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61862"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186604"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.06.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.01.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069639"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2016.48"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100061"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112519109"}],"container-title":["Immunology &amp; 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