{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:28:03Z","timestamp":1780990083110,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["18\/1003"],"award-info":[{"award-number":["18\/1003"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eosinophils play divergent roles in health and disease, contributing to both immunoregulatory and proinflammatory responses. Helminth infection is strongly associated with eosinophilia and the induction of the type 2 cytokines interleukin (IL)\u20105, IL\u20104 and IL\u201013. This study aimed to elucidate the heterogeneity of pulmonary eosinophils in response to helminth infection and the roles of IL\u20105, IL\u20104 and IL\u201013 in driving pulmonary eosinophil responses. Using the murine helminth model <jats:italic>Nippostrongylus brasiliensis<\/jats:italic> (<jats:italic>Nb<\/jats:italic>), we characterize a subtype of eosinophils, defined by high expression of CD101, that is induced in the lungs of <jats:italic>Nb<\/jats:italic>\u2010infected mice and are phenotypically distinct from lung eosinophils that express low levels of CD101. Strikingly, we show that the two eosinophil subtypes have distinct anatomical localization within the lung: CD101<jats:sup>low<\/jats:sup> eosinophils are predominantly localized in the lung vasculature, whereas <jats:italic>Nb<\/jats:italic>\u2010induced CD101<jats:sup>hi<\/jats:sup> eosinophils are predominantly localized in the extravascular lung niche. We show that CD101<jats:sup>hi<\/jats:sup> eosinophils are also induced across other models of pulmonary infection and inflammation, including a nonlung\u2010migrating helminth infection, house dust mite\u2013induced allergic inflammation and influenza infection. Furthermore, we demonstrate that the induction of CD101<jats:sup>hi<\/jats:sup> tissue eosinophils is independent of IL\u20105 and IL\u20104 signaling, but is dependent on intact IL\u201013 signaling. These results suggest that IL\u201013 produced during helminth infection and other disease states promotes a pulmonary tissue\u2010infiltrating program in eosinophils defined by high expression of CD101.<\/jats:p>","DOI":"10.1111\/imcb.12796","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T07:13:55Z","timestamp":1719386035000},"page":"734-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Helminth infection induces a distinct subset of CD101<sup>hi<\/sup> lung tissue\u2013infiltrating eosinophils that are differentially regulated by type 2 cytokines"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-7160","authenticated-orcid":false,"given":"Sophia\u2010Louise","family":"Noble","sequence":"first","affiliation":[{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"},{"name":"Department of Medicine University of 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