{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:01:53Z","timestamp":1784401313120,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>UNC93B1 is essential for the stability and endosomal trafficking of nucleic\u2010acid sensing Toll\u2010like receptors (TLRs) including TLR7 and TLR8. Increased TLR7 responses are associated with lupus autoimmunity in both mice and humans. In a recent article, Al\u2010Azab <jats:italic>et\u00a0al.<\/jats:italic> demonstrate the role of a variant of <jats:italic>UNC93B1<\/jats:italic> (p.V117L) in the induction of pediatric systemic lupus erythematosus in patients and in mice through TLR7\/8 hyperresponsiveness. They also highlight a potential role for the pharmacological inhibition of interleukin\u20101 receptor\u2013associated kinase (IRAK) 1 and\/or 4 in ameliorating disease.<\/jats:p>","DOI":"10.1111\/imcb.12807","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:15:12Z","timestamp":1720570512000},"page":"651-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["UNCovering new causes of monogenic systemic lupus erythematosus"],"prefix":"10.1111","volume":"102","author":[{"given":"Julia I","family":"Ellyard","sequence":"first","affiliation":[{"name":"Division of Immunology and Infectious Diseases, John Curtin School of Medical Research The Australian National University  Acton ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3740-698X","authenticated-orcid":false,"given":"Michael P","family":"Gantier","sequence":"additional","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research  Clayton VIC Australia"},{"name":"Department of Molecular and Translational Science Monash University  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06726"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00291"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.011"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128346"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04642-z"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-024-01660-6"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01846-5"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.008"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adi9575"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20232005"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adi9769"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20232066"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-023-00847-3"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.842"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.12807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:19:25Z","timestamp":1725841165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.12807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/imcb.12807"],"URL":"https:\/\/doi.org\/10.1111\/imcb.12807","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}