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Recent research shows that eosinophils play important immunoregulatory roles across various tissue sites including the gastrointestinal tract, adipose tissue, lung, liver, heart, muscles, thymus and bone marrow. With recent advances in our knowledge and appreciation of eosinophil immunoregulatory functions at these tissue sites, as well as emerging research demonstrating the existence of distinct subsets of eosinophils, a review of this topic is timely. Although some questions remain regarding eosinophil function and heterogeneity, this review summarizes the contemporary understanding of the immunoregulatory roles of eosinophils across various tissues and discusses the latest research on eosinophil heterogeneity and subsets.<\/jats:p>","DOI":"10.1111\/imcb.12819","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T15:53:28Z","timestamp":1726242808000},"page":"775-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The immunoregulatory potential of eosinophil subsets"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-7160","authenticated-orcid":false,"given":"Sophia\u2010Louise","family":"Noble","sequence":"first","affiliation":[{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"},{"name":"University of Otago  Wellington New 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