{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:51:39Z","timestamp":1790254299588,"version":"4.1.0"},"reference-count":125,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peritoneal adhesion (PA) refers to the abnormal adhesion of the peritoneum either with the peritoneum itself or with tissues and organs that is caused by abdominopelvic surgery, abdominal infection or peritoneal inflammation. PA is associated with various clinical complications, such as abdominal pain and distension, intestinal obstruction, gastrointestinal disorders and female infertility, and adversely affects the quality of life of patients. Macrophages are essential for PA formation and can undergo polarization into classically activated macrophages (M1) and alternatively activated macrophages (M2), which are influenced by the peritoneal microenvironment. By releasing proinflammatory cytokines and reactive oxygen species, M1 macrophages promote peritoneal inflammatory reactions and the resultant formation of adhesion. In contrast, M2 macrophages secrete anti\u2010inflammatory cytokines and growth factors to inhibit PA formation and to promote repair and healing of peritoneal tissues, and thereby play a significant anti\u2010inflammatory role. This review comprehensively explores the function and mechanism of macrophages and their subtypes in PA formation to gain insight into the prevention and treatment of PA based on the modulation of macrophages.<\/jats:p>","DOI":"10.1111\/imcb.12831","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T20:24:42Z","timestamp":1730233482000},"page":"31-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The multiple roles of macrophages in peritoneal adhesion"],"prefix":"10.1111","volume":"103","author":[{"given":"Shangwei","family":"Yang","sequence":"first","affiliation":[{"name":"Gansu University of Chinese Medicine  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhe","family":"Zheng","sequence":"additional","affiliation":[{"name":"Digestive Department The First People's Hospital of Lanzhou New Area  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Pu","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Nian","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8685-8272","authenticated-orcid":false,"given":"Junliang","family":"Li","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine  Lanzhou China"},{"name":"Department of General Surgery Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.782224","article-title":"PuraStat RADA16 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