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To determine the role of mouse MGL1 in colitis\u2010associated colon cancer (CAC), azoxymethane (AOM)\/dextran sodium sulfate (DSS)\u2010induced tumor development was compared between <jats:italic>Mgl1<\/jats:italic> knockout (<jats:italic>Mgl1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) mice and their wild\u2010type (WT) littermates. At 75\u2009days post\u2010CAC induction, colon tumor tissue contained more highly glycosylated proteins, representing potential ligands for the mMGL1 receptor, than did healthy colon tissue. The <jats:italic>Mgl1<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> CAC mice scored lower in disease activity indices and had fewer colonic tumors. In addition, the colonic crypt architecture was less damaged, and mucin production was more significant than in the WT CAC mice. Furthermore, <jats:italic>Mgl1<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> CAC mice displayed higher percentages of CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T\u00a0cells in the peripheral blood, and colonic lamina propria; and lower percentages of myeloid\u2010derived suppressor cells (MDSCs). Additionally, less macrophage (M\u03c6) and natural killer (NK) cell infiltration and lower levels of iNOS and arginase were found in the tumor microenvironment of <jats:italic>Mgl1<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> CAC mice compared with WT mice. These results suggest that the mMGL1 receptor may recognize aberrant glycosylation in colon cancer, which may trigger an inflammatory microenvironment and favor colon tumorigenesis.<\/jats:p>","DOI":"10.1111\/imcb.70011","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:13:08Z","timestamp":1741759988000},"page":"444-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The macrophage galactose\u2010type C\u2010type lectin 1 receptor plays a major role in mediating colitis\u2010associated colorectal cancer malignancy"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-144X","authenticated-orcid":false,"given":"Oscar","family":"Nieto\u2010Ya\u00f1ez","sequence":"first","affiliation":[{"name":"Innate Immunity Laboratory, Biomedicine Research Unit (UBIMED), Facultad de Estudios Superiores Iztacala (FES\u2010Iztacala) Universidad Nacional 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