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The mechanisms by which phagocytosis eradicates malaria parasites, particularly <jats:italic>Plasmodium falciparum<\/jats:italic>, remain incompletely understood and warrant further investigation. In this context, previous studies have shown that various factors such as phagocyte cell subclasses, plasma protein molecules and <jats:italic>Plasmodium<\/jats:italic> evasion tactics influence the phagocytic process differently. However, the mechanisms underlying phagocytic activity during <jats:italic>P. falciparum<\/jats:italic> infections are still ambiguous. In this review, we summarize key immunological aspects and current knowledge of phagocytic activity during <jats:italic>P. falciparum<\/jats:italic> infection. We highlight the significant involvement of distinct active cells that induce phagocytosis. 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