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The transcription factor promyelocytic leukemia zinc finger (PLZF) is crucial for defining the function of MAIT\u00a0cells and other unconventional T\u00a0cells; however, the transcriptional programs that direct MAIT\u00a0cell development are not fully elucidated. Here, we show that the canonical NF\u2010\u03baB transcription factor RelA is critical for MAIT\u00a0cell thymic development, but not responsiveness to antigen, whereas NF\u2010\u03baB1 and c\u2010Rel make more limited contributions. MAIT\u00a0cell development is also impaired in the absence of the linear ubiquitin signaling complex (LUBAC), an upstream regulator of NF\u2010\u03baB signaling, implicating this pathway in establishing the MAIT\u00a0cell pool. Collectively, these data suggest LUBAC and NF\u2010\u03baB signals as elements of the transcriptional network controlling MAIT\u00a0cell development.<\/jats:p>","DOI":"10.1111\/imcb.70096","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:11:05Z","timestamp":1772957465000},"page":"329-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    transcription factor\n                    <scp>RelA<\/scp>\n                    directs mucosal\u2010associated invariant T\u2010cell development"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-5739","authenticated-orcid":false,"given":"Thomas S","family":"Fulford","sequence":"first","affiliation":[{"name":"Department of Microbiology &amp; Immunology at the Peter Doherty 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