{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:41:41Z","timestamp":1776055301352,"version":"3.50.1"},"reference-count":88,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastrointestinal symptoms have emerged as a common, but underappreciated, cause of morbidity in relation to SARS\u2010CoV\u20102 infection and the COVID\u201019 pandemic. This manifests as a range of indications including diarrhea, anorexia, nausea, vomiting and abdominal pain. In addition, the gastrointestinal tract may represent a route of viral entry via the epithelial cell layer lining the gut wall. This route of entry could be a significant component of disease pathogenesis, including effects on the nervous system via the gut\u2010brain axis. In this review, we provide an assessment of the effects of COVID\u201019 on the gastrointestinal system, its involvement in disease severity and potential pathways for viral entry and infection in the gastrointestinal tract. We also examine evidence that gut\u2010derived serotonin is affected by SARS\u2010CoV\u20102 infection, how this may link to symptoms and disease pathogenesis and the potential link to the efficacy of selective serotonin reuptake inhibitors in reducing COVID\u201019 severity.<\/jats:p>","DOI":"10.1111\/imcb.70097","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:03:52Z","timestamp":1773018232000},"page":"368-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of peripheral serotonin in\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102 infectivity,\n                    <scp>COVID<\/scp>\n                    \u201019 treatment and long\n                    <scp>COVID<\/scp>"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-6170","authenticated-orcid":false,"given":"Daniel W","family":"Thorpe","sequence":"first","affiliation":[{"name":"Gut Sensory Systems Group, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4841-8847","authenticated-orcid":false,"given":"Lauren A","family":"Jones","sequence":"additional","affiliation":[{"name":"Gut Sensory Systems Group, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-8307","authenticated-orcid":false,"given":"Alyce M","family":"Martin","sequence":"additional","affiliation":[{"name":"Gut Sensory Systems Group, Flinders Health and 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